Abstract: 　Objective　To explore the clinical characteristics and influencing factors of hyponatremia in children with systemic lupus erythematosus (SLE). Methods　The clinical data of 83 children with SLE from January 2011 to January 2019 were analyzed retrospectively. According to the blood sodium value, they were divided into hyponatremia group and nonhyponatremia group. The clinical manifestations and laboratory examination results of the two groups were compared. Results Compared with non-hyponatremia group, children in hyponatremia group had a higher incidence of renal lesions, obviously elevated levels of blood sedimentation, C-reactive protein, interleukin 6 (IL-6) and IL-1 levels, and increased SLE disease activity index (SLEDAI), and reduced levels of serum chlorine, albumin and complement C3, and the differences were statistically significant (all P<0.05). There was no difference in white blood cell count, aspartate transaminase, lactate dehydrogenase, urea nitrogen, and creatinine (all P> 0.05). Conclusions　SLE combined with hyponatremia in children is more likely to develop kidney damage. Hyponatremia may be related to severe inflammatory response.

Key words: systemic lupus erythematosus;　hyponatremia;　child