Abstract: 　Objective　To explore the relationship between cow's milk protein allergy and gastric antrum polyps in infants. Method　The clinical data of gastrointestinal obstruction due to gastric antral hyperplastic polyps confirmed by electronic gastroscopy and histopathology in 2 children were retrospectively analyzed. Results　One boy and one girl, aged 7 months and 11 months respectively, were presented with repeated vomiting and malnutrition. Both of them were suspected of congenital hypertrophic pyloric stenosis by abdominal ultrasonography and the girl was treated with pyloric ring myotomy. The painless gastroscopy showed that polypoid hyperplasia near the gastric antrum resulted in complete obstruction of the gastric output tract in two children, and jejunal tube was placed during the operation. The cow’s milk specific IgE was 0.43 IU/mL and 1.35 IU/mL respectively in two children, and the milk protein allergy was confirmed by stimulation test. Two children were fed the amino acid formula through the jejunal tube continuously, and were treated with oral hormone therapy at the same time. Two months later, the gastroscopy was reexamined, and the gastric antrum polyps were significantly shrunk, and they could eat by themselves. Conclusion　Gastric antrum polyps are rare in infants and may be associated with milk protein allergy in 2 cases.

Key words: 　gastric antrum polyp;　milk protein allergy;　amino acid formula;　gastric outlet obstruction;　congenital hypertrophic pyloric stenosis