Abstract: Objective　To investigate the relationships of serum uric acid with clinical and pathological manifestations in children with Henoch-Sch?nlein purpura nephritis (HSPN). Methods　The clinical data of 82 children with HSPN were retrospectively analyzed. According to the levels of serum uric acid, these children were divided into hyperuricemia group (43 cases) and normal serum uric acid group (39 cases). The correlation of serum uric acid level with clinical indicators and pathological manifestations was analyzed, and the serum uric acid levels of children with different clinical subtypes of HSPN were analyzed. Results　Compared with the normal uric acid group, the 24-hour urinary protein content, serum creatinine level and blood cholesterol level were higher in the hyperuricemia group, while the serum albumin level and glomerular filtration rate were lower in the hyperuricemia group. The differences were statistically significant (P<0.05). Compared with the normal uric acid group, the proportion of pathological grading ⅠtoⅡwas lower, the proportion of crescent formation ≥25% was higher, and the proportion of renal tubular atrophy score of 1 and 2 was higher in the hyperuricemia group. The differences were statistically significant (P<0.05). The serum uric acid level of the children with isolated hematuria, isolated proteinuria, hematuria and proteinuria was lower than that of the children with nephrotic proteinuria, and the difference was statistically significant (P?

Key words: serum uric acid;　Henoch-Sch?nlein purpura nephritis;　pathology;　clinical manifestation;　child