Abstract: Objective To explore the clinical characteristics of infantile cholestatic liver diseases and non-cholestatic liver diseases. Methods? The clinical data of liver disease in infants were retrospectively analyzed, and the clinical differences between cholestatic and non-cholestatic liver disease in infants were compared. Results Among 1985 children ( 866 males and 1119 females) aged (2.88±3.088) months at admission, there were 477 cases (24.0%) of cholestasis, and 1 508 cases (76.0%) of non-cholestasis. Univariate analysis showed that the age of cholestasis infants was younger than that in non-cholestasis infants, and the levels of total bilirubin, direct bilirubin, γ-glutamyltranspeptidase, alkaline phosphatase and total bile acid were higher than those in non-cholestasis infants. The differences were statistically significant (all P< 0 . 05 ). Multivariate logistic regression analysis showed that with the higher levels of γ-glutamyltranspeptidase, alkaline phosphatase and total bile acid, the age and albumin level were lower and the possibility of cholestasis was higher. Conclusions Compared with non-cholestatic liver disease in childhood, cholestatic liver disease has earlier onset and higher levels of gamma glutamyltranspeptidase, alkaline phosphatase and total bile acid, which may help the differentiation in clinic.

Key words: cholestasis; congenital biliary atresia; infant