Abstract: Objective? To investigate the clinical and pathological features of children with chronic kidney disease (CKD). Methods? The clinical and pathological data of 1002 hospitalized children with CKD were retrospectively analyzed. Results? Among the 1002 children with CKD included in the study, the male to female ratio was 1 . 7: 1 and the median age of onset was 7 years. 973 patients with CKD I, 4 patients with CKD II, 7 patients with CKD III, 6 patients with CKD IV, and CKD V 12 cases. The deposit disease is mainly acquired glomerulopathy in 390 cases of primary nephrotic syndrome ( 38 . 9%), 372 cases of Henoch-Sch?nlein purpura nephritis ( 37. 1%), and 100 cases of IgA nephropathy ( 10%). Pathological classification included 108 cases of nephropathy and 594 cases of non-minor lesions. 990 cases were fully followed up, 12 were lost and 4 died, with a median follow-up of 894 days. Conclusion? Acquired glomerular disease is the main cause of CKD in children. The pathological changes are mainly non-minimal lesions. Early diagnosis and intervention are the key factors to delay the progression to end-stage renal failure in children with CKD.

Key words: chronic kidney disease;? clinical feature;? pathology;? child