Abstract: Objective To Explore the value of receptor interacting protein 3 (RIP 3 ) in the diagnosis of neonatal sepsis. Methods A total of 36 children with sepsis admitted to the neonatal department from September 2019 to May 2020 were included in the sepsis group, and 36 children with non-infectious diseases during the same period were used as the control group. The plasma RIP 3 level was detected by enzyme-linked immunosorbent assay (ELISA), C-reactive protein (CRP) was detected by immunoturbidimetry, and platelet count (PLT) was performed by automatic hematology analyzer. The differences of RIP 3 , CRP and PLT were compared before and after treatment and between the two groups, and the diagnostic value of the above three indicators for sepsis was evaluated by ROC curve. Results The difference of RIP 3 , CRP and PLT were statistically significant (P< 0 . 05 ) before and after treatment in sepsis group and between the sepsis group and the control group. The levels of RIP 3 and CRP before treatment in the sepsis group were higher than those after treatment and in the control group, and the PLT level was lower than that after treatment in the control group, and the differences were statistically significant (P< 0 . 05 ). When RIP 3 ≥ 15 . 91 ng/mL, CRP> 8 mg/L, and PLT< 100 × 109 /L, the sensitivity of the three indicators for the diagnosis of neonatal sepsis was 77 . 8 %, 58 . 3 % and 13 . 9 %, and the specificity was 91 . 7 ,%, 91 . 7 % and 88 . 9 % respectively. When RIP 3, CRP, and PLT were combined to diagnose neonatal sepsis, the sensitivity, specificity, and ROC area under the curve were 86 . 1 %, 97 . 2 % and 93 . 9 % respectively. Conclusions The expression level of plasma RIP 3 is related to the onset of neonatal sepsis. The combined detection of RIP3 , CRP and PLT has a high diagnostic value for neonatal sepsis.

Key words: sepsis; receptor interacting protein 3; neonate