Abstract: Objective Analyze the clinical features and pathogenesis of Miller-Fisher syndrome (MFS) in children. Methods The clinical data of 19 patients with MFS who were hospitalized in children’s Hospital Affiliated to Chongqing Medical University from 2010 to 2020 were retrospectively analyzed, including the inducement, onset form, clinical manifestation, auxiliary examination, treatment and efficacy of all patients. Results Among the 19 cases, 14 were male and 5 were female, with an average age of 4 years and 7 months. The main manifestations were ophthalmoplegia, ataxia, weakening or disappearance of tendon reflex, accompanied by facial paralysis, dysarthria, muscle or joint pain, fatigue, dysphagia and so an. Cerebrospinal fluid (CSF) was examined in 18 children, 14 of whom had CSF protein cell separation. The neuroelectrophysiological examination showed that the peripheral nerve and nerve root were damaged. Ganglioside antibody was detected in 6 children, and no abnormality was found in MRI or CT. All the patients were treated with nutritional nerve therapy. In addition, 3 patients were treated with hormone alone, 12 patients were treated with gamma globulin alone, and 3 patients were treated with gamma globulin and hormone. The clinical symptoms of all the patients were significantly improved at the time of discharge. Conclusions The clinical manifestations of children with MFS are highly complex and atypical. We should pay attention to the detailed history and physical examination, and actively improve the detection of cerebrospinal fluid, neuroelectrophysiological examination and ganglioside antibody to make a clear diagnosis. The prognosis was good after treatment with gamma globulin or hormone.

Key words: Miller-Fisher syndrome; clinical characteristics; pathogenesis; child