›› 2014, Vol. 32 ›› Issue (1): 80-82.

• Original Article • Previous Articles     Next Articles

Progress of research in immune mechanism of human cytomegalovirus evasion of natural killer cells Reviewer: SUN Min, Reviser: QIAN Jihong (Department of Neonatology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China)

  

  • Received:2013-07-21 Published:2014-01-15 Online:2014-01-15

Abstract:  Human cytomegalovirus (HCMV) is a member of β-herpesvirus subfamily, with a high infection rate, worldwide spread. It can hardly be eliminated completely after primary infection, causing lifelong, persistent infections. NK cells play a vital role in the innate immunity. HCMV adopts a series of measures to avoid the NK cell killing. The immune evasion mechanism is very complicated, such as encoding host gene homologue, microRNA. This article review the mechanisms by which the HCMV evade the NK cell killing.