吸附无细胞百白破灭活脊髓灰质炎和b型流感嗜血杆菌（结合）联合疫苗的安全性和免疫原性的meta分析

Abstract

Abstract: 　Objective　To evaluate the effectiveness and safety of DTaP-IPV/Hib combined vaccine in comparison with commercially available DTaP (diphtheria, tetanus and pertussis), Haemophilus influenzae type b (Hib), tetanus conjugate and IPV monovalent vaccine. Methods Randomized controlled trials (RCTs) on DTaP-IPV/Hib were retrieved by searching international and national databases. The pooled mean difference and relative risk and 95% CI were assessed by meta analysis with RevMan 5.0 software. Results Totally 6 studies were included for the final analysis. The seroprotection/seroconversion level of the Anti-PT (RR=0.26, 95%CI: 0.14, 0.48) in combination vaccine was higher. The antibody titer levels of Anti-PT (WMD=21.11, 95%CI: 9.36, 32.86), Anti-polio type1 (WMD=59.15, 95%CI: 2.81, 115.48), Anti-polio type 3 (WMD=169.82, 95%CI: 75.33, 264.30) were higher respectively. But the antibody titer level of Anti-PRP (WMD=-3.58, 95%CI: -5.52, -1.64) in the combination vaccine group was lower. Redness (RR=0.82, 95%CI: 0.72, 0.93) and Tenderness (RR=0.45, 95%CI: 0.30, 0.65) were lower in the combination vaccine. Swelling (RR=2.03, 95%CI: 1.02, 4.01) was more common in the patients given the combination vaccine. Conclusions This study supports the conclusion that the DTaP-IPV/Hib combination vaccine is equivalent to the separate injections based on similar antibody responses to the vaccine antigens, effectiveness and safety after primary doses.

REN Sisi,WANG Dongfang,ZHONG Zhaohui . Immunogenicity and safety of the acellular pertussis, diphtheria, tetanus, inactivated poliomyelitis, Haemophilus influenza type b conjugate vaccine (DTaP-IPV/Hib combined vaccine): a meta-analysis [J]., 2014, 32(3): 271-277.

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Immunogenicity and safety of the acellular pertussis, diphtheria, tetanus, inactivated poliomyelitis, Haemophilus influenza type b conjugate vaccine (DTaP-IPV/Hib combined vaccine): a meta-analysis

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