Abstract: Objective To evaluate the clinical features, treatment scheme and long-term outcomes of stage 1-2 childhood Neuroblastoma (NB). Methods The retrospective study included 49 newly diagnosed NB stage 1-2 patients from June 1998 to December 2010. Clinical data and long-term outcomes were analyzed. Results Twenty-four patients with stage 1 NB and twenty-five patients with stage 2 NB were found among all 237 patients with NB enrolled in this study. The median age at diagnosis was 25 months（２ week to９ year old），29 males and 20 females. 31 patients (63.6%) without symptoms were discovered with tumor by physical or imaging examination. Thorax and abdomen were the most common sites of primary tumor (21 and 22 cases, accounting for 42.9% and 44.9% of all patients, respectively) .40 (81.6%) NB patients had favorable pathology classification. One patient was of MYCN amplification status. Urine vanilla mandelic acid was normal in 32 (91.4%) patients, and serum lactate dehydrogenase was less than five times of the normal value in all patients. Ten NB patients were treated according to the low-risk protocol who received surgery alone.Thirty-nine patients were treated according to intermediate-risk protocol who received both surgery and chemotherapy. All the patients achieved very good partial remission (VGPR) (100%).The median follow-up period was 60 months （22 months to148months）。Nine patients were lost after a follow up of 3 months in median. The 2-、3-、5-year event free survival (EFS) and overall survial (OS) of all 49 patients was 100%. Conclusions The prognosis for neuroblastoma of stage 1-2 in this study was with 100% survival, which provides opportunity for further reduction of dosage and/or duration of episodes in chemotherapy.