›› 2014, Vol. 32 ›› Issue (5): 489-493.

• Original Article • Previous Articles     Next Articles

The research progress of galactose-deficient IgA1 in the related kidney diseases    

Reviewer: Zhang Yuheng, Reviser: Gao Jin    

  1. (Inner Mongolia Medical University, Hohhot 010059 ,Neimenggu ,China)
  • Received:2014-01-21 Online:2014-05-15 Published:2014-05-15

Abstract: In recent years, IgA nephropathy and Henoch-Sch?nlein purpura nephritis attract more and more attention on their unclear pathogenesis, single diagnostic criteria, long duration and poor prognosis, etc.. Research suggests that IgA nephropathy and purpura nephritis are IgA immune complex diseases, and serum galactose-deficient is elevated in patients with these two diseases, which might become a noninvasive biomarker for the diagnosis, prognosis prediction and disease development monitoring for IgA nephropathy and purpura nephritis. Galactose-deficient IgA1 is reviewed for its discovery, structure, process, the possible pathogenic mechanism and its significance in details in this paper.