Abstract: Objective　To investigate the clinical features and prognosis of children with rotavirus gastroenteritis and convulsion. Methods　Clinical data of children with rotavirus gastroenteritis hospitalized from January 2010 to December 2013 were retrospectively analyzed. Subjects were divided into the seizure group and no seizure group according to the presence of seizure in the course and compared between the two groups. Results　There were no significant differences in sex, age, and the average duration of hospitalization between two groups (all P>0.05). The family history, history of seizures, the levels of serum sodium, calcium, lactate, standard bicarbonate concentration (SB), actual bicarbonate concentration (AB), carbon dioxide content (TCO2) and pH were statistically significant between two groups (all P>0.05). During the follow-up period (outpatient telephone follow-up), the recurrence of seizure in two groups was significant different (P<0.05) and only one (0.54%) child in seizure group developed epilepsy. Conclusion　This study showed that rotavirus gastroenteritis with convulsion is a benign clinical course.