Abstract: 　Objective　To study the role and influence of coinfection factor to refractory Mycoplasma pneumoniae （MP） pneumonia (RMPP) in children. Methods　Clinical data and sputum specimen of 286 hospitalized children of RMPP were collected from January, 2013 to December, 2015. According to the results of pathogen detection, children were divided into RMPP coinfection group and simple MP infection group. Clinical features and laboratory tests were compared between the two groups. Results　The durations of fever and hospitalization of the RMPP coinfection group were 12.5（11.0-14.0）days and 12.0 （9.0-14.0）days, respectively, which were significantly longer than those of simple MP infection group, 11.0（9.0-13.0）days and 10.0（8.0-12.0）days (Z=3.947, P<0.001, Z=3.519, P<0.001). In the RMPP coinfection group, white blood cell count, the percentage of neutral granulocytes, pleteltes count, lactate dehydrogenase and the incidence of C-reaction protein (CRP) greater than 40 mg/L, and CRP greater than 100 mg/L, elevated CK-MB of were higher than those of simple MP infection group (all P<0.05), but the incidence of CRP greater than 8 mg/L and elevated ALT in the two groups showed no significant difference (both P>0.05). The incidence of pneumothorax and respiratory failure in children of RMPP coinfection group were higher than those in the simple MP infection group (χ2=5.873, P=0.015, χ2=11.995, P=0.001), but the incidence of lobar pneumonia, pleural effusion, atelectasis in the two groups had no significant difference (all P>0.05). The incidence of blood system damage, myocardial damage, skin and joint damage and electrolyte disorders in RMPP coinfection group were higher than those of simple MP infection group (all P<0.05). Conclusions　Children with RMPP coinfection tend to be with prolonged duration of fever, increased systemic inflammation, higher incidence of pulmonary and extrapulmonary complications, and longer duration of hospitalization.