Journal of Clinical Pediatrics ›› 2020, Vol. 38 ›› Issue (2): 86-.doi: 10.3969/j.issn.1000-3606.2020.02.002

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Diagnostic value of the ratio of α1-microglobulin to microalbumin in acute interstitial nephritis

 ZHANG Hongwen, LIU Xiaoyu, SU Baige, XIAO Huijie, YAO Yong   

  1. Department of Paediatrics, Peking University First Hospital, Beijing 100034, China
  • Online:2020-02-20

Abstract: Objective To explore the diagnostic value of the ratio of α1-microglobulin to microalbumin in acute interstitial nephritis. Methods Data were collected from 12 childhood acute interstitial nephritis patients from Jan. 1, 2014 to Dec. 31, 2017. The ratio of α1-microglobulin to microalbumin, and urine protein electrophoresis were monitored and analyzed. Each 10 cases of Dent disease, nephrotic syndrome, IgA nephropathy, Henoch-Sch?nlein purpura nephritis, lupus nephritis and Alport syndrome were included at the same duration as control group. Results In all the 12 cases, α1-microglobulin was increased apparently, the ratio of α1-microglobulin to microalbumin was much higher than 1, and was closely related to the percentage of low molecular weight protein in urine protein electrophoresis (P<0.05), the same as Dent disease, while the ratio was about zero in other glomerular disease groups. Conclusions The ratio of α1-microglobulin to microalbumin, if over 1, can be used as a diagnostic criteria for tubuloproteinuria.

Key words: acute interstitial nephritis; idiopathic; α1-microglobin; diagnostic value