Journal of Clinical Pediatrics ›› 2020, Vol. 38 ›› Issue (3): 161-.doi: 10.3969/j.issn.1000-3606.2020.03.001

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Electroencephalogram characteristic and brain function prognosis in children with status epilepticus

 JIN Mei1, SUN Suzhen1, CHEN Ling1, CHENG Caiyun2, SUN Hun2, XU Meixian2, GENG Wenjin2   

  1. 1. Department of Neurology, 2. Department of Pediatric Intensive Care Unit, The Children Hospital of Heibei Province, Shijiazhuang 050000, Hebei, China
  • Published:2020-04-07

Abstract:  Objective To explore the characteristics of electroencephalogram (EEG), the prognosis of brain function and the correlation between them. Methods The clinical data of status epilepticus (SE) in 33 children treated in pediatric intensive care unit (PICU) from August 2017 to July 2018 were analyzed retrospectively. The children with SE were divided into generalized convulsive status epilepticus (GCSE) and non-convulsive status epilepticus (NCSE). The prognosis of brain function was evaluated by amplitude integrated electroencephalogram (aEEG) and pediatric cerebral and overall performance category scale (PCOPCS), and the correlation between them was analyzed. Results In the 33 SE children (17 boys, 16 girls) aged from 1 month to 12 years, there were 21 cases of GCSE and 12 cases of NCSE. There were no statistically significant differences in gender, age, abnormal rate of imaging examination and incidence of complications between the two groups (P>0.05). The midazolam use and ICU stay in NCSE group were longer than those in the GCSE group (P<0.05). The GCSE group had a good prognosis of brain function in 11 cases, a poor prognosis in 5 cases, and a severe poor prognosis in 5 cases (5 deaths). In the NCSE group, there were 5 patients with poor prognosis and 7 patients with severe prognosis (5 deaths). According to the original EEG in aEEG, 10 children were classified as grade 1, 1 child as grade 2, 1 child as grade 3, and 1 child as grade 4, 15 children as grade 5, and 5 children as grade 6. There was a significant positive correlation between EEG grade and short-term prognosis of brain function (r=0.78, P<0.001), that is, the higher EEG grade had the worse prognosis of brain function. Conclusion The prognosis of GCSE and NCSE in children is different. The long-term EEG monitoring is of great significance to the prognosis of SE.

Key words: generalized convulsive status epilepticus; non-convulsive status epilepticus; electroencephalogram;  brain function prognosis; child