Abstract: Objective? To evaluate the value of the five pathological indexes (MESTC) of Oxford classification in clinical indicators and prognosis of Henoch-Sch?nlein purpura nephritis (HSPN) in children. Methods The clinicopathological data of children with HSPN diagnosed by clinical and renal biopsy from January 2014 to February 2019 were collected. Pathology reports and other data were then reclassified according to the Oxford pathological classification by two professional nephropathologists. The correlations between the five indicators of Oxford classification and clinical indicators and prognosis in children with HSPN were analyzed. Results A total of 102 children with HSPN were collected, including 55 males and 47 females, with an average age of onset of 8. 72 years ( 3. 9 - 15 years). According to the Oxford typing score, they were divided into mesangial hypercellularity (M) ( 89 cases of M 1 and 13 cases of M 0 ), endothelial hypercellularity (E) ( 62 cases of E 1 and 40 cases of E 0 ), segmental glomerulosclerosis (S) ( 39 cases of S 1 and 63 cases of S 0 ), tubular/interstitial lesions (T) ( 37 cases of T 1/T 2 and 65 cases of T 0 ), and crescent (C) ( 39 cases of C 1/C 2 and 63 cases of C 0 ). M, E, S and C lesions were correlated with International Study of Kidney Disease in Children (ISKDC) classification (P< 0. 05 ). The proportion of hematuria proteinuria in E 1 and C 1/C 2 groups was lower than that in the E 0 and C 0 groups; the proportion of nephrotic syndrome type was higher in the E 1 group than in the E 0 group, and differences were statistically significant (P< 0. 05 ). Urea nitrogen in group M 1 was higher than that in group M 0, urine protein in group E 1 was higher than that in group E 0, urea nitrogen in group S 1 was higher than that in group S 0, uric acid and creatinine in group T 1/T 2 were all higher than that in group T 0, and uric acid, creatinine and urine protein in group C 1/C 2 were all higher than that in group C 0, and differences were all significant (all P are correlated with various clinical indicators and prognosis of children with HSPN, which suggested that the Oxford classification has certain clinical application value in children with HSPN.

Key words: child;? Henoch-Sch?nlein purpura nephritis;? IgA nephropathy;? pathogenesis