Abstract:

Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE mediated food allergy in infants and young children. Acute stage is manifested as repeated vomiting and diarrhea, and severe cases can appear dehydration, lethargy, hypothermia and shock. Chronic stage can even lead to growth retardation. The diagnosis of FPIES was mainly determined by clinic history, symptom improvement after avoidance of suspected allergens, and positive oral food challenge. However, due to lacking of specific clinical manifestations and laboratory tests of FPIES, and insufficient understanding by clinicians, it often leads to delayed diagnosis or misdiagnosis, which may result in unnecessary examination and treatment. The related clinical problems of FPIES are discussed to improve the diagnosis and treatment.

Key words: food protein-induced enterocolitis syndrome, food avoidance, allergen, oral food challenge