健康儿童睁闭眼不同状态下多频段大脑磁活动研究

doi:10.12372/jcp.2022.21e0872

Abstract

Abstract:

Objective To investigate the characteristics of brain activities within multi-frequency ranges in the developing brain during eyes-open and eyes-closed. Methods The magnetoencephalography (MEG) data were recorded from 24 healthy children during eyes-open and eyes-closed. The MEG sources were localized with accumulated source imaging and analyzed in multi-frequency bands, including delta (1-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), beta (12-30 Hz), low-gamma (30-55 Hz) and high-gamma (65-90 Hz). Results Twenty-four subjects (14 boys and 10 girls) were enrolled, and the average age was (10.3±2.4) years. Compared with eyes-open, the absolute source power of alpha and beta activities during eyes-closed was increased in children, and the difference was statistically significant (P<0.01). Compared with eyes-open, the relative source power of alpha and beta activities was increased (P<0.01), while the relative source power of delta, low-gamma and high-gamma activities was decreased during eyes-closed in children, and the differences were statistically significant (P<0.05). There was no significant difference in the source location distribution of each frequency band between eyes-open and eyes-closed in children (P>0.05). Conclusions The brain activity varies significantly over a wide frequency range between eyes-open and eyes-closed in children. Eye closure can regulate brain physiological activity in a wide range of frequencies. The differences in baseline conditions between eyes-closed and eyes-open should be considered in MEG or EEG studies.

Key words: magnetoencephalography, accumulated source imaging, multi-frequency analysis, eyes-open, eyes-closed

FAN Yuying, XIANG Jing, LIU Xueyan, WANG Hua. A study of multi-frequency neuromagnetic brain activities in children with eyes-open and eyes-closed[J].Journal of Clinical Pediatrics, 2022, 40(3): 202-207.

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References 22

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频段	闭眼状态组	睁眼状态组	Z值	P
δ	2.626(1.905~3.474)	2.459(1.571~2.961)	1.51	0.130
θ	0.742(0.512~1.554)	0.781(0.440~1.258)	1.54	0.123
α	1.611(1.099~2.505)	0.663(0.435~0.968)	4.29	<0.001
β	2.009(1.515~2.094)	1.098(0.804~1.264)	4.26	<0.001
低γ	0.469(0.360~0.628)	0.417(0.296~0.560)	0.91	0.361
高γ	0.027(0.010~0.065)	0.019(0.009~0.075)	0.26	0.797

频段	闭眼状态组	睁眼状态组	Z值	P
δ	0.309(0.239~0.375)	0.398(0.297~0.459)	3.32	0.001
θ	0.115(0.071~0.144)	0.115(0.086~0.167)	1.26	0.209
α	0.223(0.141~0.317)	0.119(0.087~0.153)	4.29	<0.001
β	0.223(0.194~0.267)	0.136(0.176~0.218)	3.23	0.001
低γ	0.057(0.040~0.073)	0.065(0.048~0.115)	2.57	0.010
高γ	0.003(0.001~0.005)	0.004(0.002~0.008)	2.09	0.037

频段	脑磁源位置	闭眼状态对应数目	睁眼状态对应数目	P¹⁾
δ	脑深部区	11（45.8）	12（50.0）	1.000
	下内侧额叶皮质区	7（29.2）	7（29.2）
	楔前叶皮质区	6（25.0）	5（20.8）
θ	脑深部区	11（45.8）	12（50.0）	0.369
	下内侧额叶皮质区	6（25.0）	9（37.5）
	内侧枕叶皮质区	7（29.2）	3（12.5）
α	内侧枕叶皮质区	24（100.0）	20（83.3）	0.109
	脑深部区	0（0.0）	3（12.5）
	楔前叶皮质区	0（0.0）	1（4.2）
β	楔前叶皮质区	13（54.2）	12（50.0）	0.634
	内侧枕叶皮质区	8（33.3）	6（25.0）
	下内侧额叶皮质区	3（12.5）	6（25.0）
低γ	楔前叶皮质区	13（54.2）	11（45.8）	0.928
	缘上回区	6（25.0）	6（25.0）
	下内侧额叶皮质区	5（20.8）	7（29.2）
高γ	楔前叶皮质区	12（50.0）	11（45.8）	1.000
	缘上回区	7（29.2）	7（29.2）
	下内侧额叶皮质区	5（20.8）	6（25.0）

A study of multi-frequency neuromagnetic brain activities in children with eyes-open and eyes-closed

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