长双歧杆菌与婴幼儿肠道健康的研究进展

doi:10.12372/jcp.2022.21e0107

Abstract

Abstract:

Bifidobacterium longum is a commensal microbiota beneficial to the intestine, which is closely related to gut health during infancy. This paper reviews the physiological characteristics and the biological characteristics of genomics, metabolomics and proteomics, the prebiotic function in treating or alleviating gastrointestinal diseases in infants, and the research progress and application development prospect at home and abroad of Bifidobacterium longum. This review also analyzes the efficacy and possible mechanism of different strains of Bifidobacterium longum in the treatment of infantile functional constipation, irritable bowel syndrome and inflammatory bowel disease in order to provide scientific basis for the application of Bifidobacterium longum in clinical treatment or alleviation of gastrointestinal diseases in infants, and provide ideas for the development of Bifidobacterium longum functional strains and their in-depth research on promoting intestinal health.

Key words: Bifidobacterium longum, infant intestinal health, functional constipation, irritable bowel syndrome, inflammatory bowel disease, genomics

WU Shiyin, CAI Meiqin. Advances in Bifidobacterium longum and intestinal health during infancy[J].Journal of Clinical Pediatrics, 2022, 40(9): 715-720.

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References 31

[1]	关嘉琦, 邱冀, 岳莹雪, 等. 长双歧杆菌特性及应用研究进展[J]. 食品工业科技, 2021, 42(12): 430-438.
[2]	Bssholli-Salihu M, Kryeziu TL, Nebija D, et al. Prebiotics as excipients for enhancement of stability and functionality of Bifidobacterium longum ssp. infantis with potential application as symbiotics in food and pharmaceuticals[J]. Pharmazie, 2019, 74(6): 326-333. doi: 10.1002/ardp.18400740327
[3]	Colston JM, Taniuchi M, Ahmed T, et al. Intestinal colonization with Bifidobacterium longum subspecies is associated with length at birth, exclusive breastfeeding, and decreased risk of enteric virus infections, but not with histo-blood group antigens, oral vaccine response or later growth in three birth cohorts[J]. Front Pediatr, 2022, 10: 804798.
[4]	Chichlowski M, Shan N, Wampler JL, et al. Bifidobacterium longum subspecies infantis (B. infantis) in pediatric nutrition: current state of knowledge[J]. Nutrients, 2020, 12(6): 1581. doi: 10.3390/nu12061581
[5]	Yi DH, Kim YT, Kim CH, et al. Isolation and characterization of Bifidobacterium longum subsp. longum BCBL-583 for Probiotic Applications in Fermented Foods[J]. J Microbiol Biotechnol, 2018, 28(11): 1846-1849. doi: 10.4014/jmb.1809.09029
[6]	Díaz R, Torres-Miranda A, Orellana G, et al. Comparative genomic analysis of novel Bifidobacterium longum subsp. longum strains reveals functional divergence in the human gut microbiota[J]. Microorganisms, 2021, 9(9): 1906. doi: 10.3390/microorganisms9091906
[7]	Oki K, Akiyama T, Matsud K, et al. Long-term colonization exceeding six years from early infancy of Bifidobacterium longum subsp. longum in human gut[J]. BMC Microbiol, 2018, 18(1): 209. doi: 10.1186/s12866-018-1358-6
[8]	应聪萍, 陈卫, 张灏, 等. 一株Bifidobacterium longum CCFM760的生理特性、安全性评价和基因分析[J]. 食品与生物技术学报, 2020, 39(2): 81-88.
[9]	张程程. 中国不同地区人群肠道中长双歧杆菌的生理特性及肠道调节功能分析[D]. 江南大学, 2021.
[10]	Zhang C, Zhao Y, Jiang J, et al. Identification of the key characteristics of Bifidobacterium longum strains for the alleviation of ulcerative colitis[J]. Food Funct, 2021, 12(8): 3476-3492. doi: 10.1039/D1FO00017A
[11]	肖越. 长双歧杆菌肠道定殖的研究[D]. 江南大学, 2021.
[12]	左芳雷. 长双歧杆菌BBMN68氧胁迫应答机制的转录组学研究及差异表达基因的功能分析[D]. 中国农业大学, 2014.
[13]	Li M, Zhou X, Stanton C, et al. Comparative genomics analyses reveal the differences between B. longum subsp. infantis and B. longum subsp. longum in carbohydrate utilisation, CRISPR-cas systems and bacteriocin operons[J]. Microorganisms, 2021, 9(8): 1713. doi: 10.3390/microorganisms9081713
[14]	Du M, Xie X, Yang S, et al. Lysozyme-like Protein Produced by Bifidobacterium longum regulates human gut microbiota using in vitro models[J]. Molecules, 2021, 26(21): 6480. doi: 10.3390/molecules26216480
[15]	FANG ZF, PAN T, LI LZ, et al. Bifidobacterium longum mediated tryptophan metabolism to improve atopic dermatitis via the gut-skin axis[J]. Gut Microbes, 2022, 14(1): 2044723.
[16]	Li D, Cheng J, Zhu Z, et al. Treg-inducing capacity of genomic DNA of Bifidobacterium longum subsp. infantis[J]. Allergy Asthma Proc, 2020, 41(5): 372-385. doi: 10.2500/aap.2020.41.200064
[17]	Tjokronegoro SDP, Aavani N, Firmansyah A. Effectiveness of probiotics in the management of functional constipation in children: A randomized, double-blind, placebo-controlled trial[J]. International Journal of Probiotics and Prebiotics, 2020, 15(1): 1-6. doi: 10.37290/ijpp2641-7197.15:1-6
[18]	Russo M, Giugliano FP, Quitadamo P, et al. Efficacy of a mixture of probiotic agents as complementary therapy for chronic functional constipation in childhood[J]. Ital J Pediatr, 2017, 43(1): 24. doi: 10.1186/s13052-017-0334-3
[19]	Chen K, Liu C, Li H, et al. Infantile colic treated with Bifidobacterium longum CECT7894 and Pediococcus pentosaceus CECT8330: a randomized, double-blind, placebo-controlled trial[J]. Front Pediatr, 2021, 9: 635176.
[20]	Santas J, Fuentes MC, Tormo R, et al. Pediococcus pentosaceus CECT 8330 and bifidobacterium longum CECT 7894 show a trend towards lowering infantile excessive crying syndrome in a pilot clinical trial[J]. International Journal of Pharma and Bio Sciences, 2015, 6(2): 458-466.
[21]	闵燕华, 眭颖, 尹燕. 双歧杆菌三联活菌散联合乳果糖治疗婴幼儿功能性便秘临床疗效观察[J]. 中国现代医生, 2020, 58(6): 62-64.
[22]	权冰洁, 王瑞锋. 神曲消食口服液、双歧杆菌四联活菌片联合乳果糖治疗儿童便秘的效果评价[J]. 河南医学研究, 2021, 30(25): 4645-467.
[23]	孟媛. 长双歧杆菌微胶囊的制备及其缓解功能性便秘的效果评价[D]. 黑龙江大学, 2021.
[24]	Wang JK, Yao SK. Roles of gut microbiota and metabolites in pathogenesis of functional constipation[J]. Evid Based Complement Alternat Med, 2021, 2021: 5560310.
[25]	Astó E, Huedo P, Altadill T, et al. Probiotic properties of Bifidobacterium longum KABP042 and Pediococcus pentosaceus KABP041 show potential to counteract functional gastrointestinal disorders in an observational pilot trial in infants[J]. Front Microbiol, 2021, 12:741391. doi: 10.3389/fmicb.2021.741391
[26]	樊琳, 巩玉钰, 戴春威, 等. 肠道微生物制剂对小儿肠易激综合征肠道菌群、Th1/Th2细胞水平的影响[J]. 现代消化及介入诊疗, 2021, 26(5): 603-606.
[27]	O'mahony L, McCarthy J, Kelly P, et al. Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles[J]. Gastroenterology, 2005, 128(3): 541-551. doi: 10.1053/j.gastro.2004.11.050
[28]	Giannetti E, Maglione M, Alessandrella A, et al. A mixture of 3 Bifidobacteria decreases abdominal pain and improves the quality of life in children with irritable bowel syndrome: a multicenter, randomized, double-blind, placebo-controlled, crossover trial[J]. J Clin Gastroenterol, 2017, 51(1): e5-e10. doi: 10.1097/MCG.0000000000000528
[29]	姜友志, 陈春喜, 高海元, 等. 双歧杆菌乳杆菌三联活菌片联合蒙脱石散治疗小儿病毒感染性肠炎对炎症水平及肠道菌群的影响[J]. 国际检验医学杂志, 2022, 43(5): 580-584.
[30]	Tamaki H, Nakase H, Inoue S, et al. Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial[J]. Dig Endosc, 2016, 28(1): 67-74. doi: 10.1111/den.12553
[31]	Gasaly N, de Vos P, Hermoso MA. Impact of bacterial metabolites on gut barrier function and host immunity: a focus on bacterial metabolism and its relevance for intestinal inflammation[J]. Front Immunol, 2021, 12: 658354.

生理特性	菌株
生理特性	性能优良	性能不足
胃肠液耐受能力	B. longum UCD272^[4] B. longum FGDLZ8M1^[9]	B. longum FGDLZ4M1^[9] B. longum FBJ20M1^[10]
肠定殖能力	B. longum ATCC 15697^[4] B. longum AH1206^[11]	B. longum A1^[9] B. longum CCM 372^[10]
低聚糖利用能力	大多数长双歧杆菌能够利用低聚果糖与低聚半乳糖	不能利用低聚果糖：B. longum A1^[9] 不能利用低聚半乳糖：B. longum FBJ9M5^[9]
抗生素抗性	大多数长双歧杆菌菌株对红霉素、庆大霉素、链霉素、四环素、万古霉素和利福平敏感,不具抗性	具有四环素抗性：B. longum CCFM760^[8] 具有卡那霉素抗性：B. longum FGDLZ8M1^[9]
抗氧化能力	B. longum BBMN68^[12]	大多数长双歧杆菌对氧敏感

Advances in Bifidobacterium longum and intestinal health during infancy

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[14]	Reviewer：ZHANG Liangjuan,Reviser：WANG Baoxi. The progress in examinations of functional constipation in children #br# [J]. , 2014, 32(6): 587-590.
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