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Journal of Clinical Pediatrics ›› 2023, Vol. 41 ›› Issue (9): 703-707.doi: 10.12372/jcp.2023.22e1763

• Pediatric Grand Rounds • Previous Articles     Next Articles

  

  • Received:2023-01-17 Published:2023-09-15 Online:2023-09-05

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URL: https://jcp.xinhuamed.com.cn/EN/10.12372/jcp.2023.22e1763

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Figures/Tables 3

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项 目 生后37 h
(CRRT前)
生后83 h
(CRRT 36 h)
生后97 h
(CRRT 50 h)
生后103 h
(腹透前)
生后171 h
(腹透66 h)
生后192 h
(停腹透)
血氨/μmol·L-1 2 700 351 361 2 000 223 135
pH值 7.41 7.39 7.27 7.40 7.35 7.40
碱剩余/mmol·L-1 -3.7 4.3 1.0 1.3 -0.2 -1.2
乳酸/mmol·L-1 4.8 2.1 1.1 1.3 1.5 0.8
PT/s 12.9 11.5 11.9 14 - -
APTT/s 33.7 45.9 155.9 59.2 - -
白细胞计数×109·L-1 19.51 12.35 8.00 8.64 19.03 9.63
血红蛋白/g·L-1 190 107 112 72 137 117
血小板计数×109·L-1 208 47 20 20 124 238
尿素氮/mmol·L-1 7.8 1.0 1.0 - - 4.2
血肌酐/μmol·L-1 71 17 34 - - 44

"

References 11

[1] 邵肖梅, 叶鸿瑁, 丘小汕. 实用新生儿学[M]. 北京: 人民卫生出版社, 2019: 957-967.
[2] 中华医学会儿科学分会新生儿学组青年委员会. 新生儿高氨血症诊断与治疗的专家共识[J]. 中国当代儿科杂志, 2023, 25(5): 437-447.
[3] Häberle J, Burlina A, Chakrapani A, et al. Suggested guidelines for the diagnosis and management of urea cycle disorders: First revision[J]. J Inherit Metab Dis, 2019, 42(6): 1192-1230.
doi: 10.1002/jimd.12100 pmid: 30982989
[4] Aygun F, Varol F, AktugluZeybek C, et al. Continuous renal replacement therapy with high flow rate can effectively, safely, and quickly reduce plasma ammonia and leucine levels in children[J]. Children (Basel), 2019, 6(4): 53.
[5] Raina R, Bedoyan JK, Lichter-Konecki U, et al. Consensus guidelines for management of hyperammonaemia in paediatric patients receiving continuous kidney replacement therapy[J]. Nat Rev Nephrol, 2020, 16(8): 471-482.
doi: 10.1038/s41581-020-0267-8 pmid: 32269302
[6] Enns GM, Berry SA, Berry GT, et al. Survival after treatment with phenylacetate and benzoate for urea-cycle disorders[J]. N Engl J Med, 2007, 356(22): 2282-2292.
doi: 10.1056/NEJMoa066596
[7] 唐小晶, 王义, 赵玉娟. 新生儿遗传代谢病相关高氨血症的肾脏替代治疗进展[J]. 国际儿科学杂志, 2022, 49(7): 474-477.
[8] 彭晓婷, 李秋平. 新生儿急性腹膜透析的应用及预后进展[J]. 中华实用儿科临床杂志, 2020, 35(22): 1754-1757.
[9] 中华医学会儿科学分会新生儿学组. 连续性血液净化治疗新生儿急性肾损伤专家共识[J]. 中华儿科杂志, 2021, 59(4): 264-269.
[10] Gropman AL, Prust M, Breeden A, et al. Urea cycle defects and hyperammonemia: effects on functional imaging[J]. Metab Brain Dis, 2013, 28(2): 269-275.
doi: 10.1007/s11011-012-9348-0 pmid: 23149878
[11] Stojanovic VD, Doronjski AR, Barisic N, et al. A case of transient hyperammonemia in the newborn transient neonatal hyperammonemia[J]. J Matern Fetal Neonatal Med, 2010, 23(4): 347-350.
doi: 10.3109/14767050903168457 pmid: 19658037

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