脂质链长度与特应性皮炎相关性研究进展

doi:10.12372/jcp.2024.23e0567

Abstract

Abstract:

Atopic dermatitis (AD) is a chronic and recurrent inflammatory skin disease. There is growing evidence that skin barrier dysfunction is an important cause of AD. The lipid matrix in the outermost layer of the skin, namely the stratum corneum (SC), is essential for the skin barrier function. A large number of studies have shown that the decrease of SC lipid content, the shortening of chain length, the change of ceramide (CER) subclass levels and inflammatory responses all affect the skin barrier function of AD patients. This article reviews the relationship between the SC lipid chain length and the skin barrier function in AD patients.

Key words: stratum corneum lipid, fatty acid chain length, skin barrier, atopic dermatitis

XIA Xin, YAO Zhirong. Research progress on lipid chain length and atopic dermatitis[J].Journal of Clinical Pediatrics, 2024, 42(1): 80-84.

References 30

[1]	Weidinger S, Novak N. Atopic dermatitis[J]. Lancet, 2016, 387(10023): 1109-1122. doi: S0140-6736(15)00149-X pmid: 26377142
[2]	Yang G, Seok JK, Kang HC, et al. Skin barrier abnormalities and immune dysfunction in atopic dermatitis[J]. Int J Mol Sci, 2020, 21(8): 2867. doi: 10.3390/ijms21082867
[3]	van Smeden J, Bouwstra JA. Stratum corneum lipids: their role for the skin barrier function in healthy subjects and atopic dermatitis patients[J]. Curr Probl Dermatol, 2016, 49: 8-26. doi: 10.1159/000441540 pmid: 26844894
[4]	Elias PM. Epidermal lipids, barrier function, and desquamation[J]. J Invest Dermatol, 1983, 80(1 Suppl): 44s-49s. doi: 10.1038/jid.1983.12 pmid: 20479733
[5]	Bhattacharya N, Sato WJ, Kelly A, et al. Epidermal lipids: key mediators of atopic dermatitis pathogenesis[J]. Trends Mol Med, 2019, 25(6): 551-562. doi: S1471-4914(19)30070-X pmid: 31054869
[6]	Lorretta EU, Gerrit SG, Joke AB, et al. Increased levels of short-chain ceramides modify the lipid organization and reduce the lipid barrier of skin model membranes[J]. Langmuir, 2021, 37 (31): 9478-9489. doi: 10.1021/acs.langmuir.1c01295
[7]	Zwara A, Wertheim-Tysarowska K, Mika A. Alterations of ultra long-chain fatty acids in hereditary skin diseases-review article[J]. Front Med (Lausanne), 2021, 8: 730855.
[8]	Emmert H, Baurecht H, Thielking F, et al. Stratum corneum lipidomics analysis reveals altered ceramide profile in atopic dermatitis patients across body sites with correlated changes in skin microbiome[J]. Exp Dermatol, 2021, 30(10): 1398-1408. doi: 10.1111/exd.v30.10
[9]	Janssens M, van Smeden J, Gooris GS, et al. Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients[J]. J Lipid Res, 2012, 53(12): 2755-2766. doi: 10.1194/jlr.P030338 pmid: 23024286
[10]	van Smeden J, Janssens M, Kaye EC, et al. The importance of free fatty acid chain length for the skin barrier function in atopic eczema patients[J]. Exp Dermatol, 2014, 23(1): 45-52. doi: 10.1111/exd.12293 pmid: 24299153
[11]	Fujii M. The pathogenic and therapeutic implications of ceramide abnormalities in atopic dermatitis[J]. Cells, 2021, 10(9): 2386. doi: 10.3390/cells10092386
[12]	Mojumdar EH, Helder RW, Gooris GS, et al. Monounsaturated fatty acids reduce the barrier of stratum corneum lipid membranes by enhancing the formation of a hexagonal lateral packing[J]. Langmuir, 2014, 30 (22): 6534-6543. doi: 10.1021/la500972w pmid: 24818519
[13]	Berdyshev E, Goleva E, Bronova I, et al. Lipid abnormalities in atopic skin are driven by type 2 cytokines[J]. JCI Insight, 2018, 3(4): e98006. doi: 10.1172/jci.insight.98006
[14]	Uche LE, Gooris GS, Bouwstra JA, et al. Barrier capability of skin lipid models: effect of cramides and free fatty acid composition[J]. Langmuir, 2019, 35(47): 15376-15388. doi: 10.1021/acs.langmuir.9b03029
[15]	Beddoes CM, Rensen DE, Gooris GS, et al. The importance of free fatty chain length on the lipid organization in the long periodicity phase[J]. Int J Mol Sci, 2021, 22(7): 3679. doi: 10.3390/ijms22073679
[16]	Uchiyama M, Oguri M, Mojumdar EH, et al. Free fatty acids chain length distribution affects the permeability of skin lipid model membranes[J]. Biochim Biophys Acta, 2016, 1858(9): 2050-2059. doi: S0005-2736(16)30209-7 pmid: 27287726
[17]	Boer DEC, van Smeden J, Al-Khakany H, et al. Skin of atopic dermatitis patients shows disturbed β-glucocerebrosidase and acid sphingomyelinase activity that relates to changes in stratum corneum lipid composition[J]. Biochim Biophys Acta Mol Cell Biol Lipids, 2020, 1865(6): 158673.
[18]	Danso M, Boiten W, van Drongelen V, et al. Altered expression of epidermal lipid bio-synthesis enzymes in atopic dermatitis skin is accompanied by changes in stratum corneum lipid composition[J]. J Dermatol Sci, 2017, 88(1): 57-66. doi: S0923-1811(16)30793-9 pmid: 28571749
[19]	Dharmage SC, Lowe AJ, Matheson MC, et al. Atopic dermatitis and the atopic march revisited[J]. Allergy, 2014, 69(1): 17-27. doi: 10.1111/all.12268 pmid: 24117677
[20]	Marenholz I, Kerscher T, Bauerfeind A, et al. An interaction between filaggrin mutations and early food sensitization improves the prediction of childhood asthma[J]. J Allergy Clin Immunol, 2009, 123(4): 911-916. doi: 10.1016/j.jaci.2009.01.051 pmid: 19348926
[21]	Lodge CJ, Lowe AJ, Gurrin LC, et al. House dust mite sensitization in toddlers predicts current wheeze at age 12 years[J]. J Allergy Clin Immunol, 2011, 128(4): 782-788. doi: 10.1016/j.jaci.2011.06.038 pmid: 21820717
[22]	Elias PM. Optimizing emollient therapy for skin barrier repair in atopic dermatitis[J]. Ann Allergy Asthma Immunol, 2022, 128(5): 505-511. doi: 10.1016/j.anai.2022.01.012
[23]	Danso MO, van Drongelen V, Mulder A, et al. TNF-α and Th2 cytokines induce atopic dermatitis-like features on epidermal differentiation proteins and stratum corneum lipids in human skin equivalents[J]. J Invest Dermatol, 2014, 134(7): 1941-1950. doi: S0022-202X(15)36873-1 pmid: 24518171
[24]	Tawada C, Kanoh H, Nakamura M, et al. Interferon-γ decreases ceramides with long-chain fatty acids: possible involvement in atopic dermatitis and psoriasis[J]. J Invest Dermatol, 2014, 134(3): 712-718. doi: S0022-202X(15)36691-4 pmid: 24008422
[25]	Kanoh H, Ishitsuka A, Fujine E, et al. IFN-γ reduces epidermal barrier function by affecting fatty acid composition of ceramide in a mouse atopic dermatitis model[J]. J Immunol Res, 2019, 2019: 3030268.
[26]	Ishida K, Takahashi A, Bito K, et al. Treatment with synthetic pseudoceramide improves atopic skin, switching the ceramide profile to a healthy skin phenotype[J]. J Invest Dermatol, 2020, 140(9): 1762-1770. doi: S0022-202X(20)30127-5 pmid: 32014509
[27]	Sahle FF, Gebre-Mariam T, Dobner B, et al. Skin diseases associated with the depletion of stratum corneum lipids and stratum corneum lipid substitution therapy[J]. Skin Pharmacol Physiol, 2015, 28(1): 42-55. doi: 10.1159/000360009
[28]	Shin KO, Kim S, Park BD, et al. N-Palmitoyl serinol stimulates ceramide production through a CB1-dependent mechanism in In vitro model of skin inflammation[J]. Int J Mol Sci, 2021, 22(15): 8302. doi: 10.3390/ijms22158302
[29]	Wen S, Ye L, Liu D, et al. Topical N-palmitoyl serinol, a commensal bacterial metabolite, prevents the development of epidermal permeability barrier dysfunction in a murine model of atopic dermatitis-like skin[J]. Can J Vet Res, 2021, 85(3): 201-204. pmid: 34248264
[30]	Zhong Y, Samuel M, van Bever H, et al. Emollients in infancy to prevent atopic dermatitis: a systematic review and meta-analysis[J]. Allergy, 2022, 77(6): 1685-1699. doi: 10.1111/all.v77.6

Research progress on lipid chain length and atopic dermatitis

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[2]	XIANG Juan, WANG Hua, LIU Huan, et al. Relationship between severity of disease and serum levels of fat-soluble vitamins in children with atopic dermatitis [J]. Journal of Clinical Pediatrics, 2019, 37(8): 578-.
[3]	KONG Yuwei. Research progress on cytokines in atopic dermatitis [J]. Journal of Clinical Pediatrics, 2019, 37(2): 148-.
[4]	LI Meiyun, XIE Li, HE Huan, et al. The correlation between severity of atopic dermatitis and vitamin D level in children [J]. Journal of Clinical Pediatrics, 2019, 37(10): 727-.
[5]	XU Qianyue. Role and mechanism of eosinophils in the pathogenesis of atopic dermatitis [J]. , 2017, 35(5): 389-.
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