Abstract: 　Objective　To study the clinical features, treatment and prognosis of neonatal hand-foot-mouth disease. Methods　Neonatal hand-foot-mouth disease patients admitted from July 2014 to May 2016 were retrospectively studied. EV71, CA16 and universal enterovirus were detected from newborn swabs by RT-PCR. Results　A total of 8 neonatal patients with hand-foot-mouth diseases, 6 boys and 2 girls were diagnosed at an age ranged from 7-26 days. Of them, 7 patients had exposure history. Clinical manifestations including rash (8 cases), fever (6 cases), irritability (4 cases) and vomiting (1 case), nobody suffered convulsions. The results of RT-PCR showed pathogen enterovirus not- EV71 and not-CA16. There were 5 cases of pulmonary infection treated with antibiotic therapy. All of the 8 cases had a good prognosis. Conclusions　Most of the handfoot-mouth diseases had exposure history without specific clinical manifestations. They had not- EV71 and not-CA16 intestinal virus infection, some patients had pulmonary infection. Therefore, neonatal hand-foot-mouth diseases need more clinical attention.