Abstract: Objective　To analyze the influence factors of pathogenesis, clinical manifestations, microscopic morphology and histopathology in children with colonic polyps. Methods　193 cases of colonic polyps were collected in the children’s hospital of Soochow University during the period of July 2010 to July 2015. According to the length of the course, all cases were divided into two groups: short-term group (6 months or less), long-term group (> 6 months). Results　There were 131 boys and 62 girls. The average age was 4.61±2.16 years old. The average disease duration was 7.29±8.30 months (one week to 4 years). There was no significant difference between the two groups in the rate of underweight and anemia, the level of hemoglobin, serum albumin and pre-albumin (P >0.05); The main clinical manifestation included hematochezia (98.7%), abdominal pain (17.10%) and protruding tumor (13.47%); The colonoscopy found 197 polyps, in which 189 were single polyp (95.94%), and 8 were multiple polyps (4.06%). Nine polyps (4.57%) were in the right colon, and 188 polyps (95.43%) in the left colon. All of the polyps were divided into 3 groups: huge polyps group (> 1.5 cm), large polyps group (0.5～1.5 cm), and small polyps group (＜0.5 cm）. There were 17 cases found with small polyps (8.63%), 119 cases with large polyps (60.40%), and 61 cases with huge polyps (30.96%). Between the three groups, there was no significant difference in age, gender, and duration of the disease (P＞0.05). Histopathologic examination showed that most polyps were juvenile polyps (98.69%), inflammatory polyp account for 1.31%. No adenomatous polyps and malignant polyps were found. Conclusions　Hematochezia, abdominal pain and anal tumor are the main complains of colonic polyps in children, there was no significant difference in age and gender. The colonic polyps only have few effects on nutritional status, growth and development in children. Constipation and atopic constitution may be important factors in the development of colonic polyps. The size of colonic polyps has no close relationship with the age, gender and duration of the disease.