Abstract:

Congenital high airway obstruction syndrome (CHAOS) is a rare syndrome caused by complete or nearly complete airway obstruction of the fetus, including any airway obstruction that interrupts the amniotic fluid circulation between the fetal lungs and the amniotic cavity. Its causes are various, most of them are congenital malformations, and airway obstruction can also be caused by external compression (such as primary cervical mass or double aortic arch). If prenatal disorders can be found in time and given corresponding treatments, it is of great help to reduce perinatal mortality. At present, most of the domestic studies on CHAOS are case reports and prenatal ultrasound screening, there are few studies related to gene defects, so it is particularly important to develop a more systematic diagnosis and treatment plan.

Key words: congenital high airway obstruction syndrome, airway disease, newborn