Abstract:

Systemic lupus erythematosus (SLE) is a serious multi-system autoimmune disease, and the vast majority of patients are women of childbearing age. The fetus, newborns and offspring in the long term will be affected by the SLE during pregnancy, including stillbirth, miscarriage, placental abruption, intrauterine growth retardation and the increase in preterm birth incidence. A few cases can also cause neonatal lupus (NL), and even have negative effect on the neurocognition of offspring. Moreover, women with SLE need oral medications before and during pregnancy to control the disease, which will affect offspring in most cases. Therefore, it is recommended that patients with SLE are monitored closely before and during pregnancy. Meanwhile, the optimized treatment and overall evaluation of their offspring will be applied to reduce the adverse effects on the offspring. The effect of SLE during pregnancy on offspring and its mechanism is summarized in this paper by literature review. The effects of drugs for SLE during pregnancy on offspring were also discussed.

Key words: systemic lupus erythematosus, pregnancy, offspring