肺炎支原体疫苗研究进展

doi:10.12372/jcp.2022.21e1322

Abstract

Abstract:

Mycoplasma pneumoniae (MP) is one of the main pathogens of community-acquired pneumonia, which can cause respiratory symptoms and other extrapulmonary complications. Macrolide antibiotics are the first choice for the treatment of MP infection. In recent years, with the increase of MP infection rate and the wide application of antibiotics, the situation of macrolide drug resistance is becoming more and more serious. Vaccine is the best scientific method to prevent and control the prevalence, infection and pathogenicity of germs. At present, animal MP vaccine has been marketed at home and abroad and achieved good protective effects, while MP vaccine for human is still in the research stage. Based on this, the MP related vaccine is reviewed in order to provide some reference for the development of human MP vaccine in the future.

Key words: Mycoplasma pneumoniae, subunit vaccines, epitope peptide vaccines, DNA vaccines, live vector vaccines

ZHANG Haiqing, CHEN Yanping, ZHANG Jin. Research progress of Mycoplasma pneumoniae vaccine[J].Journal of Clinical Pediatrics, 2022, 40(8): 634-640.

References 42

[1]	Nakane D, Kenri T, Matsuo L, et al. Systematic structural analyses of attachment organelle in Mycoplasma pneumoniae[J]. PLoS Pathog, 2015, 11(12): e1005299.
[2]	Guo DX, Hu WJ, Wei R, et al. Epidemiology and mechanism of drug resistance of Mycoplasma pneumoniae in Beijing, China: a multicenter study[J]. Bosn J Basic Med Sci, 2019, 19(3): 288-296.
[3]	Qu J, Chen S, Bao F, et al. Molecular characterization and analysis of Mycoplasma pneumoniae among patients of all ages with community-acquired pneumonia during an epidemic in China[J]. Int J Infect Dis, 2019, 83: 26-31. doi: 10.1016/j.ijid.2019.03.028
[4]	Zhao F, Li J, Liu J, et al. Antimicrobial susceptibility and molecular characteristics of Mycoplasma pneumoniae isolates across different regions of China[J]. Antimicrob Resist Infect Control, 2019, 8: 143. doi: 10.1186/s13756-019-0576-5
[5]	Somes MP, Turner RM, Dwyer LJ, et al. Estimating the annual attack rate of seasonal influenza among unvaccinated individuals: a systematic review and meta-analysis[J]. Vaccine, 2018, 36(23): 3199-3207.. doi: 10.1016/j.vaccine.2018.04.063
[6]	Yu Q, Li X, Fan M, et al. The impact of childhood pneumococcal conjugate vaccine immunisation on all-cause pneumonia admissions in Hong Kong: a 14-year population-based interrupted time series analysis[J]. Vaccine, 2021, 39(19): 2628-2635. doi: 10.1016/j.vaccine.2021.03.090
[7]	Prentice S, Nassanga B, Webb EL, et al. BCG-induced non-specific effects on heterologous infectious disease in Ugandan neonates: an investigator-blind randomised controlled trial[J]. Lancet Infect Dis, 2021, 21(7): 993-1003. doi: 10.1016/S1473-3099(20)30653-8 pmid: 33609457
[8]	Linchevski I, Klement E, Nir-Paz R. Mycoplasma pneumoniae vaccine protective efficacy and adverse reactions--systematic review and meta-analysis[J]. Vaccine, 2009, 27(18): 2437-2446. doi: 10.1016/j.vaccine.2009.01.135 pmid: 19368785
[9]	Smith CB, Friedewald WT, Chanock RM. Inactivated Mycoplasma pneumoniae vaccine. Evaluation in volunteers[J]. JAMA, 1967, 199(6): 353-358. doi: 10.1001/jama.1967.03120060051007
[10]	Unni PA, Ali AMMT, Rout M, et al. Designing of an epitope-based peptide vaccine against walking pneumonia: an immunoinformatics approach[J]. Mol Biol Rep, 2019, 46(1): 511-527. doi: 10.1007/s11033-018-4505-0
[11]	Rodman Berlot J, Krivec U, Mrvič T, et al. Mycoplasma pneumoniae P 1 genotype indicates severity of lower respiratory tract infections in children[J]. J Clin Microbiol, 2021, 59(8): e0022021. doi: 10.1128/JCM.00220-21
[12]	Williams CR, Chen L, Sheppard ES, et al. Distinct Mycoplasma pneumoniae interactions with sulfated and sialylated receptors[J]. Infect Immun, 2020, 88(11): e00392-20.
[13]	Chaudhry R, Ghosh A, Chandolia A. Pathogenesis of Mycoplasma pneumoniae: an update[J]. Indian J Med Microbiol, 2016, 34(1): 7-16. doi: 10.4103/0255-0857.174112 pmid: 26776112
[14]	Widjaja M, Berry IJ, Jarocki VM, et al. Cell surface processing of the P1 adhesin of Mycoplasma pneumoniae identifies novel domains that bind host molecules[J]. Sci Rep, 2020, 10(1): 6384. doi: 10.1038/s41598-020-63136-y
[15]	Chourasia BK, Chaudhry R, Malhotra P. Delineation of immunodominant and cytadherence segment(s) of Mycoplasma pneumoniae P1 gene[J]. BMC Microbiol, 2014, 14: 108. doi: 10.1186/1471-2180-14-108
[16]	Schurwanz N, Jacobs E, Dumke R. Strategy to create chimeric proteins derived from functional adhesin regions of Mycoplasma pneumoniae for vaccine development[J]. Infect immun, 2009, 77(11): 5007-5015. doi: 10.1128/IAI.00268-09 pmid: 19667041
[17]	贾飞勇, 梁东, 傅文永, 等. 肺炎支原体P1蛋白预防动物支原体肺炎的研究[J]. 中华儿科杂志, 2001, 39(5): 293-295.
[18]	Meng YL, Wang WM, Lv DD, et al. The effect of platycodin D on the expression of cytoadherence proteins P1 and P30 in Mycoplasma pneumoniae models[J]. Environ Toxicol Pharmacol, 2017, 49: 188-193. doi: 10.1016/j.etap.2017.01.001
[19]	Kenri T, Kawakita Y, Kudo H, et al. Production and characterization of recombinant P1 adhesin essential for adhesion, gliding, and antigenic variation in the human pathogenic bacterium, Mycoplasma pneumoniae[J]. Biochem Biophys Res Commun, 2019, 508(4): 1050-1055. doi: 10.1016/j.bbrc.2018.11.132
[20]	Drasbek M, Christiansen G, Drasbek KR, et al. Interaction between the P1 protein of Mycoplasma pneumoniae and receptors on HEp-2 cells[J]. Microbiology (Reading), 2007, 153(Pt 11): 3791-3799. doi: 10.1099/mic.0.2007/010736-0
[21]	朱翠明, 汪世平, 吴移谋, 等. 肺炎支原体P1蛋白片段免疫学活性及黏附功能的研究[J]. 中华微生物学和免疫学杂志, 2012, 32(8): 706-710.
[22]	Varshney AK, Chaudhry R, Kabra SK, et al. Cloning, expression, and immunological characterization of the P30 protein of Mycoplasma pneumoniae[J]. Clin vaccine immunol, 2008, 15(2): 215-220. doi: 10.1128/CVI.00283-07 pmid: 18032594
[23]	Hausner M, Schamberger A, Naumann W, et al. Development of protective anti-Mycoplasma pneumoniae antibodies after immunization of guinea pigs with the combination of a P1-P30 chimeric recombinant protein and chitosan[J]. Microb Pathog, 2013, 64: 23-32. doi: 10.1016/j.micpath.2013.07.004
[24]	Tabassum I, Chaudhry R, Chourasia BK, et al. Identification of an N-terminal 27 kDa fragment of Mycoplasma pneumoniae P116 protein as specific immunogen in M. pneumoniae infections[J]. BMC Infect Dis, 2010, 10: 350. doi: 10.1186/1471-2334-10-350 pmid: 21144026
[25]	Svenstrup HF, Nielsen PK, Drasbek M, et al. Adhesion and inhibition assay of Mycoplasma genitalium and M. pneumoniae by immunofluorescence microscopy[J]. J Med Microbiol, 2002, 51(5): 361-373. doi: 10.1099/0022-1317-51-5-361 pmid: 11990488
[26]	Vizarraga D, Kawamoto A, Matsumoto U, et al. Immunodominant proteins P1 and P40/P90 from human pathogen Mycoplasma pneumoniae[J]. Nat Commun, 2020, 11(1): 5188. doi: 10.1038/s41467-020-18777-y pmid: 33057023
[27]	Chen C, Yong Q, Jun G, et al. Designing, expression and immunological characterization of a chimeric protein of Mycoplasma pneumoniae[J]. Protein Pept Lett, 2016, 23(7): 592-596. doi: 10.2174/0929866523666160502155414
[28]	Chen Y, Wu Y, Qin L, et al. T-B cell epitope peptides induce protective immunity against Mycoplasma pneumoniae respiratory tract infection in BALB/c mice[J]. Immunobiology, 2021, 226(3): 152077. doi: 10.1016/j.imbio.2021.152077
[29]	Vilela Rodrigues TC, Jaiswal AK, de Sarom A, et al. Reverse vaccinology and subtractive genomics reveal new therapeutic targets against Mycoplasma pneumoniae: a causative agent of pneumonia[J]. R Soc Open Sci, 2019, 6(7): 190907. doi: 10.1098/rsos.190907
[30]	Ramasamy K, Balasubramanian S, Manickam K, et al. Mycoplasma pneumoniae community-acquired respiratory distress syndrome toxin uses a novel KELED sequence for retrograde transport and subsequent cytotoxicity[J]. mBio, 2018, 9(1): e01663-17.
[31]	Balasubramanian S, Pandranki L, Maupin S, et al. Disulfide bond of Mycoplasma pneumoniae community-acquired respiratory distress syndrome toxin is essential to maintain the ADP-ribosylating and vacuolating activities[J]. Cell Microbiol, 2019, 21(8): e13032.
[32]	Kannan TR, Baseman JB. ADP-ribosylating and vacuolating cytotoxin of Mycoplasma pneumoniae represents unique virulence determinant among bacterial pathogens[J]. Proc Natl Acad Sci U S A, 2006, 103(17): 6724-6729. doi: 10.1073/pnas.0510644103 pmid: 16617115
[33]	Medina JL, Brooks EG, Chaparro A, et al. Mycoplasma pneumoniae CARDS toxin elicits a functional IgE response in Balb/c mice[J]. PLoS One, 2017, 12(2): e0172447. doi: 10.1371/journal.pone.0172447
[34]	Zhu C, Wang S, Hu S, et al. Protective efficacy of a Mycoplasma pneumoniae P1C DNA vaccine fused with the B subunit of Escherichia coli heat-labile enterotoxin[J]. Can J Microbiol, 2012, 58(6): 802-810. doi: 10.1139/w2012-051
[35]	Lin L, Qiao M, Zhang X, et al. Site-selective reactions for the synthesis of glycoconjugates in polysaccharide vaccine development[J]. Carbohydr Polym, 2020, 230: 115643. doi: 10.1016/j.carbpol.2019.115643
[36]	Brunner H. Protective efficacy of Mycoplasma pneumoniae polysaccharides[J]. Isr J Med Sci, 1981, 17(7): 678-681. pmid: 6793538
[37]	Razin S, Prescott B, Chanock RM. Immunogenicity of Mycoplasma pneumoniae glycolipids: a novel approach to the production of antisera to membrane lipids[J]. Proc Natl Acad Sci U S A, 1970, 67(2): 590-597. pmid: 4943173
[38]	Meyer Sauteur PM, Graça C, et al. Antibodies to protein but not glycolipid structures are important for host defense against Mycoplasma pneumoniae[J]. Infect Immun, 2019, 87(2): e00663-18.
[39]	Jiang MJ, Liu S J, Su L, et al. Intranasal vaccination with Listeria ivanovii as vector of Mycobacterium tuberculosis antigens promotes specific lung-localized cellular and humoral immune responses[J]. Sci Rep, 2020, 10(1): 302. doi: 10.1038/s41598-019-57245-6
[40]	Mahdy SE, Sijing L, Lin S, et al. Development of a recombinant vaccine against foot and mouth disease utilizing mutant attenuated Listeria ivanovii strain as a live vector[J]. J Virol Methods, 2019, 273: 113722. doi: 10.1016/j.jviromet.2019.113722
[41]	Gerlach T, Elbahesh H, Saletti G, et al. Recombinant influenza A viruses as vaccine vectors[J]. Expert Rev Vaccines, 2019, 18(4): 379-392. doi: 10.1080/14760584.2019.1582338 pmid: 30777467
[42]	Mara AB, Gavitt TD, Tulman ER, et al. Lipid moieties of Mycoplasma pneumoniae lipoproteins are the causative factor of vaccine-enhanced disease[J]. NPJ Vaccines, 2020, 5(1): 31. doi: 10.1038/s41541-020-0181-x

Research progress of Mycoplasma pneumoniae vaccine

RichHTML

PDF (PC)

Like

Knowledge

Abstract

Cite this article

share this article

References 42

Related Articles 3

Metrics

Comments

Recommended 0

[1]	GAO Longfei, ZHANG Jingli, WU Xiaojie, WU Huifang, DUAN Chenchu, KANG Juncong, ZHANG Zhongping. Predictive role of IL-17A in refractory Mycoplasma pneumoniae pneumonia in children [J]. Journal of Clinical Pediatrics, 2023, 41(5): 366-369.
[2]	GUO Fang, KANG Lei, DU Feifan, JIA Yanhong, XU Meixian. Myelin oligodendrocyte glycoprotein antibody-associated disease in children with prominent manifestation of optic neuritis caused by Mycoplasma pneumoniae infection: a case report [J]. Journal of Clinical Pediatrics, 2023, 41(10): 703-707.
[3]	LIU Feng. Clinical indicators related to prognosis of Mycoplasma pneumoniae pneumonia [J]. Journal of Clinical Pediatrics, 2022, 40(4): 247-251.