新型冠状病毒感染对哮喘儿童肺功能影响

doi:10.12372/jcp.2022.23e0163

Abstract

Abstract:

The pandemic of COVID-19 raises new challenges in the management of pediatric asthma. We analyzed airway injury in children with asthma from molecular mechanism to pathological alterations and explored the effect of SARS-CoV-2 on pulmonary function, which will inform clinicians in the diagnosis and management of childhood asthma in the context of the new coronavirus epidemic.

Key words: respiratory virus, SARS-CoV-2, lung function, bronchial asthma, child

WANG Jinrong, MIAO Yu, MA Guangzeng, CAO Luofei. Effect of SARS-CoV-2 infection on pulmonary function in children with asthma[J].Journal of Clinical Pediatrics, 2023, 41(5): 333-338.

References 44

[1]	World Health Organization. WHO Coronavirus (COVID-19)[EB/OL]. [2022-02-25]. https://covid19.who.int.
[2]	No authors listed. The global asthma report 2022[J]. Int J Tuberc Lung Dis, 2022, 26(1): 1-104.
[3]	Campos C, Prokopich S, Loewen H, et al. Long-term effect of COVID-19 on lung imaging and function, cardiorespiratory symptoms, fatigue, exercise capacity, and functional capacity in children and adolescents: a systematic review and meta-analysis[J]. Healthcare (Basel), 2022, 10(12): 2492.
[4]	Seibold MA, Moore CM, Everman JL, et al. Risk factors for SARS-CoV-2 infection and transmission in households with children with asthma and allergy: a prospective surveillance study[J]. J Allergy Clin Immunol, 2022, 150(2): 302-311. doi: 10.1016/j.jaci.2022.05.014 pmid: 35660376
[5]	Kompaniyets L, Agathis NT, Nelson JM, et al. Underlying medical conditions associated with severe COVID-19 illness among children[J]. JAMA Netw Open, 2021, 4(6): e2111182. doi: 10.1001/jamanetworkopen.2021.11182
[6]	Shi T, Pan J, Katikireddi SV, et al. Risk of COVID-19 hospital admission among children aged 5-17 years with asthma in Scotland: a national incident cohort study[J]. Lancet Respir Med, 2022, 10: 191-198. doi: 10.1016/S2213-2600(21)00491-4
[7]	Chiang CY, Ellwood P, Ellwood E, et al. Infection with SARS-CoV-2 among children with asthma: evidence from Global Asthma Network[J]. Pediatr Allergy Immunol, 2022, 33(1): e13709.
[8]	Pivniouk V, Pivniouk O, DeVries A, et al. The OM-85 bacterial lysate inhibits SARS-CoV-2 infection of epithelial cells by downregulating SARS-CoV-2 receptor expression[J]. J Allergy Clin Immunol, 2022, 149(3): 923-933.. doi: 10.1016/j.jaci.2021.11.019
[9]	Tay MZ, Poh CM, Rénia L, et al. The trinity of COVID-19: immunity, inflammation and intervention[J]. Nat Rev Immunol, 2020, 20(6): 363-374. doi: 10.1038/s41577-020-0311-8 pmid: 32346093
[10]	Vora SM, Lieberman J, Wu H. Inflammasome activation at the crux of severe COVID-19[J]. Nat Rev Immunol, 2021, 21(11): 694-703. doi: 10.1038/s41577-021-00588-x pmid: 34373622
[11]	Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China[J]. Lancet (London, England), 2020, 395(10223): 497-506. doi: 10.1016/S0140-6736(20)30183-5
[12]	Shoenfeld Y. Corona (COVID-19) time musings: our involvement in COVID-19 pathogenesis, diagnosis, treatment and vaccine planning[J]. Autoimmun Rev, 2020, 19(6): 102538. doi: 10.1016/j.autrev.2020.102538
[13]	Zhao L, Zhang YP, Yang X, et al. Eosinopenia is associated with greater severity in patients with coronavirus disease 2019[J]. Allergy, 2021, 76: 562-564. doi: 10.1111/all.v76.2
[14]	Crook H, Raza S, Nowell J, et al. Long covid-mechanisms, risk factors, and management[J]. BMJ, 2021, 374: n1648.
[15]	Cui S, Chen S, Li X, et al. Prevalence of venous throm-boembolism in patients with severe novel coronavirus pneumonia[J]. J Thromb Haemost, 2020, 18(6): 1421-1424. doi: 10.1111/jth.14830
[16]	Torres-Castro R, Vasconcello-Castillo L, Alsina-Restoy X, et al. Respiratory function in patients post-infection by COVID-19: a systematic review and meta-analysis[J]. Pulmonology, 2021, 27: 328-337. doi: 10.1016/j.pulmoe.2020.10.013
[17]	Öztürk GK, Beken B, Doğan S, et al. Pulmonary function tests in the follow-up of children with COVID-19[J]. Eur J Pediatr, 2022, 181: 2839-2847. doi: 10.1007/s00431-022-04493-w pmid: 35522314
[18]	Soyak Aytekin E, Sahiner UM, Tuten Dal S, et al. Obesity is a risk factor for decrease in lung function after COVID-19 infection in children with asthma[J]. Pediatr Pulmonol, 2022, 57: 1668-1676. doi: 10.1002/ppul.v57.7
[19]	Choudhary S, Sharma K, Silakari O. The interplay between inflammatory pathways and COVID-19: a critical review on pathogenesis and therapeutic options[J]. Microb Pathog, 2021, 150: 104673. doi: 10.1016/j.micpath.2020.104673
[20]	D'Agnillo F, Walters KA, Xiao Y, et al. Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19[J]. Sci Transl Med, 2021, 13: eabj7790. doi: 10.1126/scitranslmed.abj7790
[21]	Du X, Yang Y, Yang Mg et al. ITGB4 deficiency induces mucus hypersecretion by upregulating MUC5AC in RSV-infected airway epithelial cells[J]. Int J Biol Sci, 2022, 18: 349-359. doi: 10.7150/ijbs.66215 pmid: 34975337
[22]	Sajuthi SP, DeFord P, Li Y, et al. Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium[J]. Nat Commun, 2020, 11(1): 5139. doi: 10.1038/s41467-020-18781-2 pmid: 33046696
[23]	Postma DS, Brightling C, Baldi S, et al. Exploring the relevance and extent of small airways dysfunction in asthma (ATLANTIS): baseline data from a prospective cohort study[J]. Lancet Respir Med, 2019, 7(5): 402-416. doi: 10.1016/S2213-2600(19)30049-9 pmid: 30876830
[24]	Ashkenazi-Hoffnung L, Shmueli E, Ehrlich S, et al. Long COVID in children: observations from a designated pediatric clinic[J]. Pediatr Infect Dis J, 2021, 40: e509-e511. doi: 10.1097/INF.0000000000003285 pmid: 34371507
[25]	Maniscalco M, Ambrosino P, Fuschillo S, et al. Bronchodilator reversibility testing in post-COVID-19 patients undergoing pulmonary rehabilitation[J]. Respir Med, 2021, 182: 106401. doi: 10.1016/j.rmed.2021.106401
[26]	Xu Z, Shi L, Wang Y, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome[J]. Lancet Respir Med, 2020, 8(4): 420-422. doi: 10.1016/S2213-2600(20)30076-X pmid: 32085846
[27]	国家儿童医学中心, 首都医科大学附属北京儿童医院新型冠状病毒感染重症救治专家组, 北京儿童新型冠状病毒感染医疗救治市级专家组. 儿童新型冠状病毒Omicron变异株感染重症早期识别和诊治建议[J]. 中华儿科杂志, 2023, 61(3): 199-202.
[28]	Faverio P, Luppi F, Rebora P, et al. Six-month pulmonary impairment after severe COVID-19: a prospective, multicentre follow-up study[J]. Respiration, 2021, 100: 1078-1087. doi: 10.1159/000518141
[29]	Xu C, Ma M, Yi Y, et al. Clinical features and high-resolution chest computerized tomography findings of children infected by the B.1.617.2 variant of coronavirus disease 2019[J]. Ann Med, 2022, 54(1): 2391-2401. doi: 10.1080/07853890.2022.2114608 pmid: 36039499
[30]	Long ME, Mallampalli RK, Horowitz JC. Pathogenesis of pneumonia and acute lung injury[J]. Clin Sci (Lond), 2022, 136(10): 747-769. doi: 10.1042/CS20210879 pmid: 35621124
[31]	Heiss R, Tan L, Schmidt S, et al. Pulmonary dysfunction after pediatric COVID-19[J]. Radiology, 2023, 306(3): e221250. doi: 10.1148/radiol.221250
[32]	Camporota L, Cronin JN, Busana M, et al. Pathophysiology of coronavirus-19 disease acute lung injury[J]. Curr Opin Crit Care e, 2022, 28(1): 9-16.
[33]	Xiao C, Puddicombe SM, Field S, et al. Defective epithelial barrier function in asthma[J]. J Allergy Clin Immunol, 2011, 128(3): 549-556. doi: 10.1016/j.jaci.2011.05.038 pmid: 21752437
[34]	Bajbouj K, Ramakrishnan RK, Hamid Q. Role of matrix metalloproteinases in angiogenesis and its implications in asthma[J]. J Immunol Res, 2021: 6645072.
[35]	Lee KS, Min KH, Kim SR, et al. Vascular endothelial growth factor modulates matrix metalloproteinase-9 expression in asthma[J]. Am J Respir Crit Care Med, 2006, 174(2): 161-170. doi: 10.1164/rccm.200510-1558OC
[36]	Lucas C, Wong P, Klein J, et al. Longitudinal analyses reveal immunological misfiring in severe COVID-19[J]. Nature, 2020, 584(7821): 463-469. doi: 10.1038/s41586-020-2588-y
[37]	Pathinayake PS, Awatade NT, Wark PAB. Type 2 immunity and its impact on COVID-19 infection in the airways[J]. Viruses, 2023, 15(2): 402. doi: 10.3390/v15020402
[38]	Roberts LM, Jessop F, Wehrly TD, et al. CuttinG EDGE: LUNG-RESident T cells elicited by SARS-CoV-2 do not mediate protection against secondary infection[J]. J Immunol, 2021, 207(10): 2399-404. doi: 10.4049/jimmunol.2100608 pmid: 34607940
[39]	Rahimi RA, Nepal K, Cetinbas M, et al. Distinct functions of tissue-resident and circulating memory Th2 cells in allergic airway disease[J]. J Exp Med, 2020, 217(9) : e20190865.
[40]	May BC, Gallivan KH. Levocetirizine and montelukast in the COVID-19 treatment paradigm[J]. Int Immu-nopharmacol, 2022, 103: 108412.
[41]	Mera-Cordero F, Bonet-Monne S, Almeda-Ortega J, et al. Double-blind placebo-controlled randomized clinical trial to assess the efficacy of montelukast in mild to moderate respiratory symptoms of patients with long COVID: E-SPERANZA COVID Project study protocol[J]. Trials, 2022, 23(1): 19. doi: 10.1186/s13063-021-05951-w pmid: 34991703
[42]	Zhang L, Wang X, Huang Y, et al. Pediatric asthma situation in Chengdu, China, during the COVID-19 pandemic: an observational study[J]. J Asthma Allergy, 2021, 14: 829-838. doi: 10.2147/JAA.S315695 pmid: 34276218
[43]	Borg Bm, Osadnik C, Adam K, et al. Pulmonary function testing during SARS-CoV-2: An ANZSRS/TSANZ position statement[J]. Respirology, 2022, 27(9): 688-719. doi: 10.1111/resp.14340 pmid: 35981737
[44]	Franczuk M, Przybyłowski T, Czajkowska-Malinowska M, et al. Spirometry during the SARS-CoV-2 pandemic. Guidelines and practical advice from the expert panel of Respiratory Physiopathology Assembly of Polish Respiratory Society[J]. Adv Respir Med, 2020, 88(6): 640-650. doi: 10.5603/ARM.a2020.0186 pmid: 33393664

Effect of SARS-CoV-2 infection on pulmonary function in children with asthma

RichHTML

PDF (PC)

Like

Knowledge

Abstract

Cite this article

share this article

References 44

Related Articles 15

Metrics

Comments

Recommended 0

[1]	ZOU Liping. Childhood encephalopathy: a group of diseases associated with various diseases [J]. Journal of Clinical Pediatrics, 2023, 41(9): 641-643.
[2]	ZHANG Weihua, ZOU Liping, REN Haitao, GUAN Hongzhi. Beware of the pitfalls in diagnosis and treatment of autoimmune encephalitis in children [J]. Journal of Clinical Pediatrics, 2023, 41(9): 644-649.
[3]	HOU Chi, CHEN Wenxiong, LIAO Yinting, WU Wenxiao, TIAN Yang, ZHU Haixia, PENG Bingwei, ZENG Yiru, WU Wenlin, CHEN Zongzong, LI Xiaojing. Clinical analysis of autoimmune glial fibrillary acidic protein astrocytopathy in children [J]. Journal of Clinical Pediatrics, 2023, 41(9): 656-660.
[4]	YANG Yating, CAI Yuehao, FANG Qiong, CHEN Lang, CHEN Qiaobin, LIN Zhi, WU Feifei, LIN Meng. Clinical analysis of idiopathic and symptomatic occipital lobe epilepsy in children [J]. Journal of Clinical Pediatrics, 2023, 41(9): 668-673.
[5]	HOU Ruolin, WU Jing, LI Ling. Pediatric autoimmune encephalitis with brain MRI showing meningeal thickening and enhancement [J]. Journal of Clinical Pediatrics, 2023, 41(9): 674-679.
[6]	WU Yuefang, SUN Yanling, WU Wanshui, DU Shuxu, LI Miao, SUN Liming. Analysis of prognostic factors and survival status of group 4 medulloblastoma in children [J]. Journal of Clinical Pediatrics, 2023, 41(9): 686-691.
[7]	SUN Juan, LI Haiying, JIA Peisheng, WANG Huaili. Clinical analysis of fulminant myocarditis in 12 children [J]. Journal of Clinical Pediatrics, 2023, 41(9): 692-696.
[8]	Reviewer: WANG Chenhui, Reviser: YANG Hui. Research progress on early screening and diagnosis of Crohn's disease in children [J]. Journal of Clinical Pediatrics, 2023, 41(9): 708-714.
[9]	SHEN Nan, DU Bailu. Strategies for the diagnosis, treatment, and management of invasive fungal infections in children with hematologic neoplasms [J]. Journal of Clinical Pediatrics, 2023, 41(8): 571-577.
[10]	XU Beixue, LIU Quanbo. Clinical analysis of 195 children with invasive pulmonary fungal infection [J]. Journal of Clinical Pediatrics, 2023, 41(8): 584-588.
[11]	CHEN Hongyu, LIU Zihao, WANG Heping, LIAO Cuijuan, LI Li, WANG Wenjian, LAI Jianwei. Role of nontypeable Haemophilus influenzae biofilms in chronic pulmonary infection in children [J]. Journal of Clinical Pediatrics, 2023, 41(8): 589-593.
[12]	KANG Lei, GUO Fang, LI Lifang, BAI Xinfeng, CHENG Caiyun, XU Meixian. Value of metagenomic next-generation sequencing in children with visceral leishmaniasis associated with hemolytic histiocytosis [J]. Journal of Clinical Pediatrics, 2023, 41(8): 594-598.
[13]	SUN Zhicai, LIU Yuling, LI Xiaolin, PAN Xiaofen. Clinical analysis of 15 children with primary nephrotic syndrome complicated with adrenal crisis [J]. Journal of Clinical Pediatrics, 2023, 41(8): 610-612.
[14]	WANG Hongxia, PAN Xiang, LU Jun. Report a case of α-ketoadipic aciduria caused by compound heterozygous variant of DHTKD1 gene [J]. Journal of Clinical Pediatrics, 2023, 41(8): 624-628.
[15]	XI Bixin, HU Qun, LIU Aiguo. Research advances of the bronchiolitis obliterans syndrome following allogeneic hematopoietic stem cell transplant in children [J]. Journal of Clinical Pediatrics, 2023, 41(8): 629-633.