Abstract: With the rapid development of epigenetics, the importance of gene transcription regulated by chromatin remodeling has been noticed recently. The SWI/SNF chromatin remodeling complex has been identified as the most crucial complex in gene regulation with highly conserved structure among species, which alter the activities of genes by shifting the microstructure of DNA, regulating gene expression. A series studies have proved that SWI/SNF chromatin remodeling complex and the main functions of the subunitstook parts in the procedure of heart development, functional mature and pathological remodeling, and have made several breakthroughs. These findings provide a new theoretical and experimental support for the occurrence and development of heart disease.This article aims to review the research progress of SWI/SNF chromatin remodeling complex in regulating heart development and pathological remodeling.