Analysis of the correlation between copy number difference of ADAM3A gene and congenital diaphragmatic hernia

  • YE Weiping ,
  • XIONG Ying ,
  • GU Hang
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  • 1.Department of Obstetrics,Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China;2. Department of Obstetrics, Changhai Hospital, Shanghai 200433, China

Received date: 2017-09-15

  Online published: 2017-09-15

Abstract

Objective To evaluate the relationship between the number of copies of genes and congenital diaphragmatic hernia by the detection of multiple loci in infants with congenital diaphragmatic hernia. Methods Multiple loci were analyzed by Microarray analysis of Affymetrix Cytoscan 750 k in 11 neonates with congenital diaphragmatic hernia, in whom 1 case was twins,and his fraternal twins were diagnosed of fetuse intestinal dilatation. Results A homozygous deletion (8 p11.22 arr[hg19]) was found in one neonate with congenital diaphragmatic hernia, and was eventually confirmed that the depolymerization of the biotin and metalloprotease (ADAM) 3A genes lead to homozygous deletion of the 1~15 exon. Conclusion The alteration of ADAM3A copy number may be the cause of congenital diaphragmatic hernia. 

Cite this article

YE Weiping , XIONG Ying , GU Hang . Analysis of the correlation between copy number difference of ADAM3A gene and congenital diaphragmatic hernia[J]. Journal of Clinical Pediatrics, 2017 , 35(9) : 655 . DOI: 10.3969/j.issn.1000-3606.2017.09.005

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