Great successes have been achieved on the pediatric renal diseases under the guidance of The Group of Nephrology, Chinese Pediatric Society, Chinese Medical Association for the past thirty years. Especially that evidence-based guidelines and related interpretation for the diagnosis and treatment of common renal diseases in children were published from 2009 to 2016 unifies and standardizes the diagnosis and treatment of common pediatric renal diseases. However there are some divergences and doubts in clinical practice, and the author makes some reflections on some aspects of the clinical application.