In recent years, the resistance of gram-negative bacteria to antibiotics has reached a critical level, and the detection rate of carbapenem-resistant Klebsiella pneumoniae (CRKP) in pediatric wards in many countries has been increasing year by year. CRKP sepsis has an insidious onset and lacks specific clinical manifestations. However, CRKP sepsis is highly pathogenic, progresses rapidly, and is prone to multiple organ failure, which can endanger the lives of children. Carbapenem antibiotics are still the main treatment for CRKP infection, and new antibiotics are also being studied. This article reviews the clinical research progress of CRKP sepsis.