Journal of Clinical Pediatrics >
Phenotypic evolution of bronchopulmonary dysplasia in premature infants
Received date: 2022-03-13
Online published: 2022-06-07
Bronchopulmonary dysplasia (BPD) is the commonest chronic lung disease in preterm infants, and is associated with increased infant mortality and respiratory incidence rate. With the progress of neonatal intensive care medicine, the phenotype of BPD has evolved from fibrocystic disease affecting late preterm infants to lung parenchyma damage and vascular growth disorder mainly affecting infants born 28 weeks ago. In this article, we evaluated the evolution of the definition, pathophysiology, imaging and clinical phenotypes of BPD in order to find new evidence-based prevention and management strategies, to improve the classification of disease phenotypes, to early identify the clinical characteristics of high-risk premature infants and improve their prognosis.
Key words： preterm infants; bronchopulmonary dysplasia; phenotype
Yingxue DING . Phenotypic evolution of bronchopulmonary dysplasia in premature infants[J]. Journal of Clinical Pediatrics, 2022 , 40(6) : 407 -412 . DOI: 10.12372/jcp.2022.22e0360
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