早产儿支气管肺发育不良的表型演变

doi:10.12372/jcp.2022.22e0360

Abstract

Abstract:

Bronchopulmonary dysplasia (BPD) is the commonest chronic lung disease in preterm infants, and is associated with increased infant mortality and respiratory incidence rate. With the progress of neonatal intensive care medicine, the phenotype of BPD has evolved from fibrocystic disease affecting late preterm infants to lung parenchyma damage and vascular growth disorder mainly affecting infants born 28 weeks ago. In this article, we evaluated the evolution of the definition, pathophysiology, imaging and clinical phenotypes of BPD in order to find new evidence-based prevention and management strategies, to improve the classification of disease phenotypes, to early identify the clinical characteristics of high-risk premature infants and improve their prognosis.

Key words: preterm infants, bronchopulmonary dysplasia, phenotype

DING Yingxue. Phenotypic evolution of bronchopulmonary dysplasia in premature infants[J].Journal of Clinical Pediatrics, 2022, 40(6): 407-412.

References 44

[1]	Bancalari E, Jain D. Bronchopulmonary dysplasia: 50 years after the original description[J]. Neonatology, 2019, 115(4): 384-391. doi: 10.1159/000497422 pmid: 30974430
[2]	Thébaud B, Goss KN, Laughon M, et al. Broncho-pulmonary dysplasia[J]. Nat Rev Dis Primers, 2019, 5(1): 78. doi: 10.1038/s41572-019-0127-7
[3]	Gilfillan M, Bhandari A, Bhandari V. Diagnosis and management of bronchopulmonary dysplasia[J]. BMJ, 2021, 375: n1974.
[4]	Jiang S, Yan W, Li S, et al. Mortality and morbidity in infants< 34 weeks' gestation in 25 NICUs in China: a prospective cohort study[J]. Front Pediatr, 2020, 8: 33. doi: 10.3389/fped.2020.00033
[5]	Lapcharoensap W, Gage SC, Kan P, et al. Hospital variation and risk factors for bronchopulmonary dysplasia in a population-based cohort[J]. JAMA Pediatr, 2015, 169(2): e143676. doi: 10.1001/jamapediatrics.2014.3676
[6]	Tracy MK, Berkelhamer SK. Bronchopulmonary dysplasia and pulmonary outcomes of prematurity[J]. Pediatr Ann, 2019, 48(4): e148-e153.
[7]	Collaco JM, McGrath-Morrow SA. Bronchopulmonary dysplasia as a determinant of respiratory outcomes in adult life[J]. Pediatr Pulmonol, 2021, 56(11): 3464-3471. doi: 10.1002/ppul.25301
[8]	Humayun J, Löfqvist C, Ley D, et al. Systematic review of the healthcare cost of bronchopulmonary dysplasia[J]. BMJ Open, 2021, 11(8): e045729. doi: 10.1136/bmjopen-2020-045729
[9]	Bancalari E, Jain D. Bronchopulmonary dysplasia: can we agree on a definition?[J]. Am J Perinatol, 2018, 35(6): 537-540. doi: 10.1055/s-0038-1637761
[10]	Jensen EA, Dysart K, Gantz MG, et al. The diagnosis of bronchopulmonary dysplasia in very preterm infants. an evidence-based approach[J]. Am J Respir Crit Care Med, 2019, 200(6): 751-759. doi: 10.1164/rccm.201812-2348OC
[11]	Hwang JS, Rehan VK. Recent advances in bronchopulmonary dysplasia: pathophysiology, prevention, and treatment[J]. Lung, 2018, 196(2): 129-138. doi: 10.1007/s00408-018-0084-z pmid: 29374791
[12]	Gallini F, Coppola M, De Rose DU, et al. Neurodevelopmental outcomes in very preterm infants: the role of severity of bronchopulmonary dysplasia[J]. Early Hum Dev, 2021, 152: 105275. doi: 10.1016/j.earlhumdev.2020.105275
[13]	Principi N, Di Pietro GM, Esposito S. Bronchopulmonary dysplasia: clinical aspects and preventive and therapeutic strategies[J]. J Transl Med, 2018, 16(1): 36. doi: 10.1186/s12967-018-1417-7 pmid: 29463286
[14]	Allen J, Panitch H. Bronchopulmonary dysplasia-A historical perspective[J]. Pediatr Pulmonol, 2021, 56(11): 3478-3489. doi: 10.1002/ppul.25341
[15]	Voynow JA. "New" bronchopulmonary dysplasia and chronic lung disease[J]. Paediatr Respir Rev, 2017, 24: 17-18.
[16]	Alvira CM, Morty RE. Can we understand the pathobiology of bronchopulmonary dysplasia?[J]. J Pediatr, 2017, 190: 27-37. doi: 10.1016/j.jpeds.2017.08.041
[17]	Walkup LL, Woods JC. Newer imaging techniques for bronchopulmonary dysplasia[J]. Clin Perinatol, 2015, 42(4): 871-887. doi: 10.1016/j.clp.2015.08.012 pmid: 26593084
[18]	Li R, Zhang J. Diagnostic value of chest CT combined with X-ray for premature infants with bronchopulmonary dysplasia[J]. Medicine (Baltimore), 2018, 97(9): e9723. doi: 10.1097/MD.0000000000009723
[19]	Higano NS, Ruoss JL, Woods JC. Modern pulmonary imaging of bronchopulmonary dysplasia[J]. J Perinatol, 2021, 41(4): 707-717. doi: 10.1038/s41372-021-00929-7 pmid: 33547408
[20]	Voskrebenzev A, Vogel-Claussen J. Proton MRI of the lung: how to tame scarce protons and fast signal decay[J]. J Magn Reson Imaging, 2021, 53(5): 1344-1357. doi: 10.1002/jmri.27122
[21]	Loi B, Vigo G, Baraldi E, et al. Lung ultrasound to monitor extremely preterm infants and predict bronchopulmonary dysplasia. a multicenter longitudinal cohort study[J]. Am J Respir Crit Care Med, 2021, 203(11): 1398-1409. doi: 10.1164/rccm.202008-3131OC
[22]	Alonso-Ojembarrena A, Lubián-López SP. Lung ultrasound score as early predictor of bronchopulmonary dysplasia in very low birth weight infants[J]. Pediatr Pulmonol, 2019, 54(9) : 1404-1409. doi: 10.1002/ppul.24410
[23]	刘敬. 肺脏超声对早产儿支气管肺发育不良的预测及诊断价值[J]. 江苏大学学报, 2022, 32(2): 1-4.
[24]	Wang SH, Tsao PN. Phenotypes of bronchopulmonary dysplasia[J]. Int J Mol Sci, 2020, 21(17): 6112. doi: 10.3390/ijms21176112
[25]	Higgins RD, Jobe AH, Koso-Thomas M, et al. Broncho-pulmonary dysplasia: executive summary of a workshop[J]. J Pediatr, 2018, 197: 300-308. doi: 10.1016/j.jpeds.2018.01.043
[26]	Glaser K, Gradzka-Luczewska A, Szymankiewicz-Breborowicz M, et al. Perinatal ureaplasma exposure is associated with increased risk of late onset sepsis and imbalanced inflammation in preterm infants and may add to lung injury[J]. Front Cell Infect Microbiol, 2019, 9: 68. doi: 10.3389/fcimb.2019.00068
[27]	Viscardi RM, Kallapur SG. Role of ureaplasma respiratory tract colonization in bronchopulmonary dysplasia pathogenesis: current concepts and update[J]. Clin Perinatol, 2015, 42(4): 719-738. doi: 10.1016/j.clp.2015.08.003 pmid: 26593075
[28]	Viscardi RM, Terrin ML, Magder LS, et al. Randomised trial of azithromycin to eradicate ureaplasma in preterm infants[J]. Arch Dis Child Fetal Neonatal Ed, 2020, 105(6): 615-622. doi: 10.1136/archdischild-2019-318122
[29]	Wang J, Dong W. Oxidative stress and bronchopulmonary dysplasia[J]. Gene, 2018, 678: 177-183. doi: 10.1016/j.gene.2018.08.031
[30]	余彦亮, 邹新英, 杨传忠. 超未成熟儿支气管肺发育不良临床特点、治疗及预后分析[J]. 临床儿科杂志, 2019, 37(1): 11-15.
[31]	Collins A. Stem-cell therapy for bronchopulmonary dysplasia[J]. Curr Opin Pediatr, 2020, 32(2): 210-215. doi: 10.1097/MOP.0000000000000862 pmid: 31833951
[32]	Li JY, Lin ZL, Wei J, et al. What is the optimal oxygen saturation for extremely premature infants? a meta analysis[J]. Zhongguo Dang Dai Er Ke Za Zhi, 2015, 17(2): 128-133.
[33]	Ramaswamy VV, Bandyopadhyay T, Nanda D, et al. Assessment of postnatal corticosteroids for the prevention of bronchopulmonary dysplasia in preterm neonates: a systematic review and network meta-analysis[J]. JAMA Pediatr, 2021, 175(6): e206826. doi: 10.1001/jamapediatrics.2020.6826
[34]	Filippone M, Nardo D, Bonadies L, et al. Update on postnatal corticosteroids to prevent or treat bronchopulmonary dysplasia[J]. Am J Perinatol, 2019, 36(S02):S58-S62.
[35]	Delara M, Chauhan BF, Le ML, et al. Efficacy and safety of pulmonary application of corticosteroids in preterm infants with respiratory distress syndrome: a systematic review and meta-analysis[J]. Arch Dis Child Fetal Neonatal Ed, 2019, 104: F137-F144.
[36]	Herting E, Härtel C, Göpel W. Less invasive surfactant administration (LISA): chances and limitations[J]. Arch Dis Child Fetal Neonatal Ed, 2019, 104(6): F655-F659.
[37]	Gupta BK, Saha AK, Mukherjee S, et al. Minimally invasive surfactant therapy versus InSurE in preterm neonates of 28 to 34 weeks with respiratory distress syndrome on non-invasive positive pressure ventilation-a randomized controlled trial[J]. Eur J Pediatr, 2020, 179(8): 1287-1293. doi: 10.1007/s00431-020-03682-9
[38]	DeMauro SB. Neurodevelopmental outcomes of infants with bronchopulmonary dysplasia[J]. Pediatr Pulmonol, 2021, 56(11): 3509-3517. doi: 10.1002/ppul.25381
[39]	Dekker J, Hooper SB, van Vonderen JJ, et al. Caffeine to improve breathing effort of preterm infants at birth: a randomized controlled trial[J]. Pediatr Res, 2017, 82(2): 290-296. doi: 10.1038/pr.2017.45
[40]	Moschino L, Zivanovic S, Hartley C, et al. Caffeine in preterm infants: where are we in 2020?[J]. ERJ Open Res, 2020, 6(1): 00330-2019.
[41]	Mandell EW, Kratimenos P, Abman SH, et al. Drugs for the prevention and treatment of bronchopulmonary dysplasia[J]. Clin Perinatol, 2019, 46(2): 291-310. doi: S0095-5108(19)30022-3 pmid: 31010561
[42]	Stewart A, Brion LP, Ambrosio-Perez I. Diuretics acting on the distal renal tubule for preterm infants with (or developing) chronic lung disease[J]. Cochrane Database Syst Rev, 2011, 2011(9): CD001817.
[43]	Euteneuer JC, Kerns E, Leiting C, et al. Inhaled bronchodilator exposure in the management of bronchopulmonary dysplasia in hospitalized infants[J]. J Perinatol, 2021, 41(1): 53-61. doi: 10.1038/s41372-020-0760-8
[44]	Rakshasbhuvankar AA, Simmer K, Patole SK, et al. Enteral vitamin A for reducing severity of bronchopulmonary dysplasia: a randomized trial[J]. Pediatrics, 2021, 147(1): e2020009985. doi: 10.1542/peds.2020-009985

Phenotypic evolution of bronchopulmonary dysplasia in premature infants

RichHTML

PDF (PC)

Like

Knowledge

Cited

Abstract

Cite this article

share this article

References 44

Related Articles 15

Metrics

Comments

Recommended 0

[1]	ZHANG Wenyan, YAO Ziming, ZHANG Xuejun, ZHANG Yaodong, WANG Lingfei, HU Xuyun, HAO Chanjuan. Genetic characteristics of TRPV4-related congenital skeletal disorder [J]. Journal of Clinical Pediatrics, 2023, 41(7): 530-536.
[2]	XU Xiao, ZHAO Lin, GONG Fangqi. Role of vascular smooth muscle cell phenotypic switching in cardiovascular diseases in children [J]. Journal of Clinical Pediatrics, 2023, 41(5): 394-400.
[3]	WANG Liping, YOU You, YIN Zhanghua, WANG Yiwen, CHEN Sun, XIA Hongping. Pulmonary vein stenosis in extremely premature infants with bronchopulmonary dysplasia: a report of two cases [J]. Journal of Clinical Pediatrics, 2023, 41(4): 289-293.
[4]	HU Xuyun, HAO Chanjuan. Genetic diagnosis and management of TRPV4 disorders [J]. Journal of Clinical Pediatrics, 2023, 41(2): 86-91.
[5]	REN Shuying, ZHANG Qin. Influencing factors of respiratory tract microecology and its significance in bronchopulmonary dysplasia [J]. Journal of Clinical Pediatrics, 2023, 41(10): 715-720.
[6]	XIA Hongping, ZHANG Yongjun. Phenotypic characteristics and treatment strategies of severe bronchopulmonary dysplasia [J]. Journal of Clinical Pediatrics, 2022, 40(6): 401-406.
[7]	LI Fang, LIU Liting. Concerns about diagnosis and treatment of bronchopulmonary dysplasia [J]. Journal of Clinical Pediatrics, 2022, 40(6): 413-419.
[8]	XU Ruzheng, JIANG Xu, SUN Bin. Clinical characteristics of bronchopulmonary dysplasia in preterm infants with gestational age <32 weeks [J]. Journal of Clinical Pediatrics, 2022, 40(6): 420-424.
[9]	WANG Lili, WU Haiying, XIE Rongrong, WANG Fengyun, CHEN Ting, CHEN Xiuli, SUN Hui, WANG Xiaoyan, ZHANG Dandan, CHEN Linqi. Analysis of genetic test results in 186 cases with short stature [J]. Journal of Clinical Pediatrics, 2022, 40(5): 349-354.
[10]	WAN Ling, CHEN Chaoying, TU Juan, LI Huarong. Analysis of SLC5A2 gene variation in 11 children with primary renal glucosuria [J]. Journal of Clinical Pediatrics, 2022, 40(12): 912-918.
[11]	LIU Xiao, CHEN Pingyang, TAN Xin, et al. A retrospective study of non-Magill forceps-assisted less invasive pulmonary surfactant administration (LISA) technique [J]. Journal of Clinical Pediatrics, 2021, 39(6): 415-.
[12]	MENG Hanyan. Research progress of extrauterine growth restriction in premature infants [J]. Journal of Clinical Pediatrics, 2021, 39(4): 304-.
[13]	LI Ruiwen. Research progress of diagnostic criteria for bronchopulmonary dysplasia [J]. Journal of Clinical Pediatrics, 2021, 39(4): 308-.
[14]	LIU Xiaoming, WANG Haixia, CHEN Jiao, et al. MEHMO syndrome caused by EIF2S3 gene mutation: a report of two cases and literature review [J]. Journal of Clinical Pediatrics, 2021, 39(3): 201-.
[15]	XU Min, HE Yan, GUO Hu. Clinical and genetic analysis of Adams-Oliver syndrome type 2 primarily with nervous system involvement [J]. Journal of Clinical Pediatrics, 2021, 39(3): 227-.