Journal of Clinical Pediatrics >
Correlation analysis of amplitude-integrated electroencephalogram follow-up indicators and neurological prognosis of very low birth weight infants
Received date: 2021-10-21
Online published: 2022-08-26
Objective To analyze the correlation between amplitude-integrated electroencephalogram (aEEG) follow-up indicators and the neurological prognosis in very low birth weight infants. Methods A total of 224 very low birth weight infants delivered from January 2016 to January 2019 were selected for aEEG monitoring within one week after birth and at 3, 6 and 12 months of corrected gestational age. According to the neurological development outcome at 12 months of corrected gestational age, the infants were divided into normal group and abnormal group, and the difference of aEEG monitoring score between the two groups was compared. Results A total of 224 very low birth weight infants (125 boys and 99 girls) were included, the gestational age was (30.01±1.49) weeks and the birth weight was (1366.64±119.43) g. At 12 months of corrected gestational age, the nervous system development outcome was normal in 153 cases and abnormal in 71 cases. Within one week of birth, there was a statistically significant difference in sleep cycle (Cy) and total (T) scores between normal and abnormal groups (P<0.05). There were significant differences in graph continuity (Co), Cy and T scores between the two groups at 3 and 6 months of corrected gestational age (P<0.05). At 12 months of corrected gestational age, there were significant differences in Co, lower bound amplitude (LB), Cy, bandwidth (B) and T scores between the two groups (P<0.05). Binary logistic regression analysis showed that Co, Cy and T scores in aEEG monitoring indexes at 12 months of corrected gestational age were significantly correlated with the nervous system development outcome of very low birth weight infants (P<0.01), and the lower the score, the greater the risk of abnormal neurodevelopmental outcome. By drawing ROC curve, Co and T scores of aEEG at 12 months of gestational age were found to have moderate predictive value for the neurological outcome of very low birth weight infants (AUC 0.71 and 0.82). Conclusions The aEEG follow-up indicators are correlated with the neurological prognosis in very low birth weight infants and have certain predictive value.
Xiaoliang ZENG , Qing MIN , Shuyuan WU . Correlation analysis of amplitude-integrated electroencephalogram follow-up indicators and neurological prognosis of very low birth weight infants[J]. Journal of Clinical Pediatrics, 2022 , 40(9) : 679 -684 . DOI: 10.12372/jcp.2022.21e1476
| [1] | 盖建芳, 冀湧, 李小艳, 等. 胎龄<28周极早早产儿58例临床分析[J]. 中国药物与临床, 2019, 19(10): 1695-1697. |
| [2] | Hollanders JJ, Schaëfer N, van der Pal SM, et al. Long-term neurodevelopmental and functional outcomes of infants born very preterm and/or with a very low birth weight[J]. Neonatology, 2019, 115(4): 310-319. |
| [3] | Nam GS, Kwak SH, Bae SH, et al. Hyperbilirubinemia and follow-up auditory brainstem responses in preterm infants[J]. Clin Exp Otorhinolaryngol, 2019, 12(2): 163-168. |
| [4] | Horber V, Fares A, Platt MJ, et al. Severity of cerebral palsy-the impact of associated impairments[J]. Neuropediatrics, 2020, 51(2): 120-128. |
| [5] | Richardson J, Goshen S, Meledin I, et al. Predictive value of early amplitude integrated EEG in extremely premature infants[J]. J Child Neurol, 2020, 35(11): 737-743. |
| [6] | Malfilâtre G, Mony L, Hasaerts D, et al. Technical recommendations and interpretation guidelines for electroencephalography for premature and full-term newborns[J]. Neurophysiol Clin, 2021, 51(1): 35-60. |
| [7] | Park KH, Kim YM, Lee YJ, et al. Predictive value of an early amplitude-integrated electroencephalogram for short-term neurologic outcomes in preterm infants[J]. Turk J Pediatr, 2020, 62(3): 367-378. |
| [8] | Yang J, Hu L, Zhang Y, et al. Gesell developmental schedules scores and the relevant factors in children with down syndrome[J]. J Pediatr Endocrinol Metab, 2020, 33(4): 539-546. |
| [9] | 谢卫珍, 杨慧, 李薇, 等. 头颅超声联合振幅整合脑电图检查对超低出生体质量儿神经系统发育结局的预测价值[J]. 中国妇幼保健, 2020, 35(23): 4630-4632. |
| [10] | 刘振青, 张茜, 程欣茹, 等. 极/超低出生体质量儿神经发育结局影响因素分析[J]. 中华实用儿科临床杂志, 2019, 34(10): 773-776. |
| [11] | Ramel SE, Haapala J, Super J, et al. Nutrition, illness and body composition in very low birth weight preterm infants: implications for nutritional management and neurocognitive outcomes[J]. Nutrients, 2020, 12(1): 145-154. |
| [12] | Okur EO, Inal-Ince D, Saglam M, et al. Physical activity patterns in children with cerebral palsy and typically developing peers[J]. Physiother Theory Pract, 2021, 37(6): 710-718. |
| [13] | Bartels EM, Korbo L, Harrison AP. Novel insights into cerebral palsy[J]. J Muscle Res Cell Motil, 2020, 41(2):265-267. |
| [14] | Gui J, Liu Y, Wang Y, et al. Physical growth and brain MRI predict the neurodevelopmental outcomes in very low birth weight infants at 2-year-old[J]. Neuro Endocrinol Lett, 2021, 42(5): 321-330. |
| [15] | Tokunaga A, Akiyama T, Miyamura T, et al. Neonatal behavior and social behavior and sensory issues in 18-month toddlers[J]. Pediatr Int, 2019, 61(12): 1202-1209. |
| [16] | Zonnenberg IA, van Dijk-Lokkart EM, van den Dungen FAM, et al. Neurodevelopmental outcome at 2 years of age in preterm infants with late-onset sepsis[J]. Eur J Pediatr, 2019, 178(5): 673-680. |
| [17] | Modabbernia A, Sandin S, Gross R, et al. Apgar score and risk of autism[J]. Eur J Epidemiol, 2019, 34(2): 105-114. |
| [18] | van der Knoop BJ, Zonnenberg IA, Verbeke JIML, et al. Additional value of advanced neurosonography and magnetic resonance imaging in fetuses at risk for brain damage[J]. Ultrasound Obstet Gynecol, 2020, 56(3): 348-358. |
| [19] | Kumar I, Singh S, Kumar A, et al. Early postnatal color Doppler changes in neonates receiving delivery room resuscitation with low 5 min Apgar score-a pilot study[J]. J Perinatol, 2021, 41(3): 486-493. |
| [20] | Yuan X, Kang W, Song J, et al. Prognostic value of amplitude-integrated EEG in neonates with high risk of neurological sequelae[J]. Ann Clin Transl Neurol, 2020, 7(2): 210-218. |
| [21] | Buttle SG, Lemyre B, Sell E, et al. Combined conventional and amplitude-integrated EEG monitoring in neonates: a prospective study[J]. J Child Neurol, 2019, 34(6): 313-320. |
| [22] | Gacio S. Amplitude-integrated electroencephalography for neonatal seizure detection. An electrophysiological point of view[J]. Arq Neuropsiquiatr, 2019, 77(2): 122-130. |
| [23] | Bourel-Ponchel E, Gueden S, Hasaerts D, et al. Normal EEG during the neonatal period: maturational aspects from premature to full-term newborns[J]. Neurophysiol Clin, 2021, 51(1): 61-88. |
| [24] | Bourel-Ponchel E, Hasaerts D, Challamel MJ, et al. Behavioral-state development and sleep-state differentiation during early ontogenesis[J]. Neurophysiol Clin, 2021, 51(1): 89-98. |
| [25] | Manacero S, Nunes ML. Longitudinal study of sleep behavior and motor development in low-birth-weight preterm children from infancy to preschool years[J]. J Pediatr (Rio J), 2021, 97(1): 44-51. |
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