Journal of Clinical Pediatrics >
The dynamic changes and application value of MUC2 and sIgA in intestinal mucus layer of infants with food allergy
Received date: 2023-09-05
Online published: 2024-04-09
Objective To dynamically monitor and analyze the changes of fecal mucin 2 (MUC2) and secretory immunoglobulin A (sIgA) levels during the clinical treatment process of infants with food allergy, and to investigate the usefulness of food allergy’s interaction with sIgA and MUC2. Methods Fifty-two infants diagnosed with food allergy who received outpatient treatment from July 2022 to June 2023 were selected as the food allergy group. Simultaneously, 52 non-allergic diseases infants were chosen as the control group. The levels of fecal MUC2 and sIgA were compared between the two groups. Results There were 23 boys and 29 girls in the food allergy group and 26 boys and 26 girls in the control group. There were no statistically significant differences in age, delivery mode, feeding method, introduction of complementary foods and family history of allergic diseases between the two groups (P>0.05). The levels of fecal MUC2 and sIgA in the food allergy group were higher than those in the control group [(37.81±14.91) μg/mL vs. (25.33±14.29) μg/mL; 182.4(150.2-202.7) μg/mL vs. 147.7(131.4-157.9) μg/mL], and the differences were statistically significant (P<0.001). At the 2nd and 4th week of follow-up, fecal MUC2 level of children with food allergy group gradually decreased, but there was no statistical significance between groups (P>0.05). The level of fecal sIgA increased gradually, and the difference between groups was statistically significant (P<0.05). Binary logistic regression and ROC curve analysis showed that fecal MUC2 and sIgA both had area under the ROC curves above 0.7 (P<0.001), and the combination of the two could increase the diagnosis specificity. Conclusions There were differences in fecal MUC2 and sIgA levels between the two groups. With the improvement of clinical symptoms of children with food allergy, fecal MUC2 levels showed a downward trend and sIgA levels gradually increased, which may serve as potential biomarkers for the diagnosis of food allergy. The two groups' fecal MUC2 and sIgA levels varied from one another. With the improvement of clinical symptoms of children with food allergy, fecal MUC2 level had a downward trend and sIgA level gradually increased, suggesting that these markers could be useful for food allergy diagnosis.
Key words： food allergy; intestinal mucus layer; mucin 2; secreted immunoglobulin A; biomarker
Nini DAI , Yajuan GAO , Jinbo SUN , Juan ZHANG , Zailing LI . The dynamic changes and application value of MUC2 and sIgA in intestinal mucus layer of infants with food allergy[J]. Journal of Clinical Pediatrics, 2024 , 42(4) : 297 -304 . DOI: 10.12372/jcp.2024.23e0852
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