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Application progress of glucagon-like peptide-2 analogues in inflammatory bowel disease
Received date: 2024-12-12
Accepted date: 2025-02-06
Online published: 2025-08-27
Glucagon-like peptide-2 is a polypeptide hormone secreted by intestinal L cells. It mainly exerts multiple physiological functions in the intestine, such as increasing blood flow, promoting nutrient absorption and enhancing barrier function, by binding to specific receptors. In the treatment of intestinal inflammation, GLP-2 has demonstrated multiple mechanisms including anti-inflammatory effects, promoting intestinal barrier repair and regulating the intestinal microbiota, and has achieved results in numerous animal experiments and clinical trials. This article summarizes the research progress of GLP-2 and its analogues in the treatment of inflammatory bowel disease, providing a basis for future research and clinical applications.
ZHOU Zhixuan , WANG Ying . Application progress of glucagon-like peptide-2 analogues in inflammatory bowel disease[J]. Journal of Clinical Pediatrics, 2025 , 43(9) : 716 -722 . DOI: 10.12372/jcp.2025.24e1343
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