Journal of Clinical Pediatrics >
Latency-intensity functions of wave Ⅴ in click and tone-burst auditory brainstem responses in infants with varying degrees of sensorineural hearing loss
Received date: 2025-07-10
Accepted date: 2025-09-01
Online published: 2025-11-28
Objective To construct the latency-intensity functions of air conduction click auditory brainstem response (c-ABR) and tone-burst ABR (Tb-ABR) waves in infants with varying degrees of sensorineural hearing loss (SNHL), providing a reference for the judgment of clinical ABR thresholds. Methods Infants aged 3 to 12 months who visited the Hearing Impairment and Vertigo Diagnosis and Treatment Center from January 2023 to May 2025 were selected as the research subjects. Wave Ⅴ latencies were compared among the three groups (normal hearing, mild SNHL, and moderate SNHL groups) under both 70 dB nHL and threshold-level intensities using c-ABR and Tb-ABR (500 Hz and 1000 Hz). Latency-intensity function models were then constructed. Results A total of 120 infants were enrolled, including 52 boys and 68 girls, with a median age of 6 (5-9) months. All infants were divided into three groups based on their air-conduction c-ABR thresholds: 90 ears in the normal hearing group, 90 ears in the mild SNHL group, and 60 ears in the moderate SNHL group. At 70 dB nHL and threshold intensity levels, significant differences in wave Ⅴ latencies were found among the three groups for c-ABR, Tb-500 Hz, and Tb-1000 Hz (P<0.01). Latency-intensity function models at 70 dB nHL were as follows, c-ABR: Y=0.013X+6.07; Tb-500 Hz: Y=0.032X+9.09; Tb-1000 Hz: Y=0.022X+8.05. Latency-intensity function models at threshold intensity levels were as follows, c-ABR: Y=-0.026X+8.98; Tb-500 Hz: Y=-0.057X+15.59; Tb-1000 Hz: Y=-0.052X+13.22. Conclusions Wave Ⅴ latencies in c-ABR, Tb-500 Hz, and Tb-1000 Hz are associated with the degree of hearing loss. The latency-intensity function models developed in this study can serve as objective references to aid clinical threshold estimation using ABR.
Key words: click ABR; tone-burst ABR; hearing loss; latency-intensity function model; infant
SHEN Jiali , MA Xiaobao , WANG Wei , WANG Lu , LOU Gaozhong , ZHAO Zhehong , JIN Yulian , YANG Jun , CHEN Jianyong . Latency-intensity functions of wave Ⅴ in click and tone-burst auditory brainstem responses in infants with varying degrees of sensorineural hearing loss[J]. Journal of Clinical Pediatrics, 2025 , 43(12) : 908 -914 . DOI: 10.12372/jcp.2025.25e0802
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