不同听力损失程度婴儿短声与短纯音听性脑干反应波Ⅴ潜伏期-强度函数构建

doi:10.12372/jcp.2025.25e0802

Abstract

Abstract:

Objective To construct the latency-intensity functions of air conduction click auditory brainstem response (c-ABR) and tone-burst ABR (Tb-ABR) waves in infants with varying degrees of sensorineural hearing loss (SNHL), providing a reference for the judgment of clinical ABR thresholds. Methods Infants aged 3 to 12 months who visited the Hearing Impairment and Vertigo Diagnosis and Treatment Center from January 2023 to May 2025 were selected as the research subjects. Wave Ⅴ latencies were compared among the three groups (normal hearing, mild SNHL, and moderate SNHL groups) under both 70 dB nHL and threshold-level intensities using c-ABR and Tb-ABR (500 Hz and 1000 Hz). Latency-intensity function models were then constructed. Results A total of 120 infants were enrolled, including 52 boys and 68 girls, with a median age of 6 (5-9) months. All infants were divided into three groups based on their air-conduction c-ABR thresholds: 90 ears in the normal hearing group, 90 ears in the mild SNHL group, and 60 ears in the moderate SNHL group. At 70 dB nHL and threshold intensity levels, significant differences in wave Ⅴ latencies were found among the three groups for c-ABR, Tb-500 Hz, and Tb-1000 Hz (P<0.01). Latency-intensity function models at 70 dB nHL were as follows, c-ABR: Y=0.013X+6.07; Tb-500 Hz: Y=0.032X+9.09; Tb-1000 Hz: Y=0.022X+8.05. Latency-intensity function models at threshold intensity levels were as follows, c-ABR: Y=－0.026X+8.98; Tb-500 Hz: Y=－0.057X+15.59; Tb-1000 Hz: Y=－0.052X+13.22. Conclusions Wave Ⅴ latencies in c-ABR, Tb-500 Hz, and Tb-1000 Hz are associated with the degree of hearing loss. The latency-intensity function models developed in this study can serve as objective references to aid clinical threshold estimation using ABR.

Key words: click ABR, tone-burst ABR, hearing loss, latency-intensity function model, infant

CLC Number:

SHEN Jiali, MA Xiaobao, WANG Wei, WANG Lu, LOU Gaozhong, ZHAO Zhehong, JIN Yulian, YANG Jun, CHEN Jianyong. Latency-intensity functions of wave Ⅴ in click and tone-burst auditory brainstem responses in infants with varying degrees of sensorineural hearing loss[J].Journal of Clinical Pediatrics, 2025, 43(12): 908-914.

Figures/Tables 5

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References 19

[1]	杨军, 陈建勇. 听障婴幼儿全面听力学诊断评估[J]. 中国听力语言康复科学杂志, 2021, 19(5): 321-326.
	Yang J, Chen JY. Comprehensive audiological assessment of hearing loss in infants and children[J]. Zhongguo Tingli Yuyan Kangfu Kexue Zazhi, 2021, 19(5): 321-326.
[2]	Choe G, Park SK, Kim BJ. Hearing loss in neonates and infants[J]. Clin Exp Pediatr, 2023, 66(9): 369-376. doi: 10.3345/cep.2022.01011
[3]	Sanfins MD, Colella-santos MF, Ferrazoli N, et al. Latency and interpeak interval values of auditory brainstem response in 73 individuals with normal hearing[J]. Med Sci Monit, 2022, 28: e937847.
[4]	Kaynakoglu B, Ceyhan S. Which stimulus should be used for auditory brainstem response in newborns; CE-Chirp® level specific versus click stimulus[J]. Int J Pediatr Otorhinolaryngol, 2023, 170: 111597. doi: 10.1016/j.ijporl.2023.111597
[5]	Kaf WA, Reiter S, Brodeur A, et al. Tone-burst auditory brainstem response and cortical potentials in diagnosis of syndromic auditory neuropathy spectrum disorder[J]. J Audiol Otol, 2023, 27(3): 153-160. doi: 10.7874/jao.2022.00192
[6]	沈佳丽, 陈建勇, 汪玮, 等. 婴儿不同频率短纯音听性脑干反应正常值研究[J]. 听力学及言语疾病杂志, 2020, 28(6): 620-624.
	Shen JL, Chen JY, Wang W, et al. Study on normal value of different frequencies of tone burst auditory brainstem response in infants[J]. Tinglixue Ji Yanyu Jibing Zazhi, 2020, 28(6): 620-624.
[7]	丁伟, 侯小娟, 张伦, 等. 不同年龄段听力正常学龄前儿童短声及短纯音ABR正常参考值研究[J]. 听力学及言语疾病杂志, 2021, 29(1): 39-42.
	Ding W, Hou XJ, Zhang L, et al. The investigation of normative values of tone burst ABR for preschool chidren[J]. Tinglixue Ji Yanyu Jibing Zazhi, 2021, 29(1): 39-42.
[8]	马孝宝, 沈佳丽, 汪玮, 等. 婴幼儿短纯音听性脑干反应阈预测模型研究[J]. 中华耳科学杂志, 2024, 22(4): 562-566.
	Ma XB, Shen JL, Wang W, et al. A predictive model for tone burst auditory brainstem response thresholds in infants[J]. Zhonghua Erkexue Zazhi, 2024, 22(4): 562-566.
[9]	罗香林, 李楚凌, 尹宝珠, 等. 听力异常儿童Chirp-ABR与click-ABR波Ⅴ阈值相关性研究[J]. 听力学及言语疾病杂志, 2015, 23(2): 200-201.
	Luo XL, Li CL, Yin BZ, et al. A comparative study of wave Ⅴ thresholds between chirp-ABR and click-ABR in children with hearing impairment[J]. Tinglixue Ji Yanyu Jibing Zazhi, 2015, 23(02): 200-201.
[10]	Norton SJ, Gorga MP, Widen JE, et al. Identification of neonatal hearing impairment: summary and recommen-dations[J]. Ear Hear, 2000, 21(5): 529-535. doi: 10.1097/00003446-200010000-00014
[11]	Sharma M, Bist SS, Kumar S. Age-related maturation of wave Ⅴ latency of auditory brainstem response in children[J]. J Audiol Otol, 2016, 20(2): 97-101. doi: 10.7874/jao.2016.20.2.97
[12]	Tabachnick AR, Toscano JC. Perceptual encoding in auditory brainstem responses: effects of stimulus frequency[J]. J Speech Lang Hear Res, 2018, 61(9): 2364-2375. doi: 10.1044/2018_JSLHR-H-17-0486
[13]	Esaki T, Yoshida T, Kobayashi M, et al. Factors influencing auditory brainstem response changes in infants[J]. Int J Pediatr Otorhinolaryngol, 2024, 185: 112094. doi: 10.1016/j.ijporl.2024.112094
[14]	Lewis JD, Kopun J, Neely ST, et al. Tone-burst auditory brainstem response wave Ⅴ latencies in normal-hearing and hearing-impaired ears[J]. J Acoust Soc Am, 2015, 138(5): 3210-3219. doi: 10.1121/1.4935516
[15]	Rance G, Tomlin D, Graydon K. Tone-burst elicited auditory brainstem responses in full-term and pre-term infants[J]. Int J Audiol, 2025, 64(4): 384-391. doi: 10.1080/14992027.2024.2341119
[16]	Moller K, Blegvad B. Brain stem responses in patients with sensorineural hearing loss monaural versus binaural stimulation. The significance of the audiogram configuration[J]. Scandinavian Audiology, 2009, 5(3): 115-127. doi: 10.3109/01050397609043104
[17]	宋戎, 陶征. 聋儿短声ABR“Ⅴ”潜伏期-强度函数的大小与听力图构型关系的研究[J]. 临床耳鼻咽喉头颈外科杂志, 2015, 29(10): 959-962.
	Song R, Tao Z. The relationship between the latency-intensity function of click ABR wave Ⅴ and the audiogram configuration[J]. Linchuang Erbiyanhou Toujing Waike Zazhi, 2015, 29(10): 959-962.
[18]	马孝宝, 沈佳丽, 汪玮, 等健听幼儿短纯音ABR波Ⅴ强度—潜伏期函数模型构建[J]. 听力学及言语疾病杂志, 2023, 31(4): 299-304.
	Ma XB, Shen JL, Wang W, et al. Function model constraction of wave V intensity-lantency based on tone burst auditory brainstem responses in infants with normal hearing[J]. Tinglixue Ji Yanyu Jibing Zazhi, 2023, 31(4): 299-304.
[19]	孙敬涛, 刘海红, 王雪瑶, 等. 听性脑干反应对于婴幼儿不同性质听力损失的应用性分析[J]. 临床耳鼻咽喉头颈外科杂志, 2022, 36(2): 120-125.
	Sun JT, Liu HH, Wang XY, et al. Application of audiotory brainstem response to different types of hearing loss in infants[J]. Linchuang Erbiyanhou Toujing Waike Zazhi, 2022, 36(2): 120-125.

组别	耳数	年龄[M(P₂₅~P₇₅)]/月	性别（男/女）
正常组	90	6(6~9)	40/50
轻度SNHL组	90	6(5~10)	36/54
中度SNHL组	60	6(3~9)	28/32
统计量		H=2.76	χ²=0.72
P		0.252	0.696

组别	耳数	c-ABR	Tb-500 Hz ABR	Tb-1000 Hz ABR	F值	P
正常组	90	6.30±0.33	10.59±0.95³⁾	8.77±0.73³⁾⁴⁾	861.14	<0.001
轻度SNHL组	90	6.58±0.62¹⁾	10.62±1.32³⁾	9.08±1.01¹⁾³⁾⁴⁾	375.43	<0.001
中度SNHL组	60	6.88±0.80¹⁾²⁾	11.14±1.18¹⁾²⁾³⁾	9.40±1.06^1)2)3)4)	262.08	<0.001
F值		17.81	5.20	7.70
P		<0.001	0.006	0.001

组别	耳数	c-ABR	Tb-500 Hz ABR	Tb-1000 Hz ABR	F值	P
正常组	90	8.51±0.59	13.45±1.07³⁾	11.55±0.96³⁾⁴⁾	761.81	<0.001
轻度SNHL组	90	8.06±0.92¹⁾	12.45±1.51¹⁾³⁾	10.68±1.36¹⁾³⁾⁴⁾	288.79	<0.001
中度SNHL组	60	7.23±0.77¹⁾²⁾	11.74±1.30¹⁾²⁾³⁾	9.91±1.21^1)2)3)4)	249.64	<0.001
F值		50.75	39.47	32.52
P		<0.001	<0.001	<0.001

项目	强度	回归方程	R²	P
c-ABR	70 dB nHL	Y=0.013X+6.07	0.163	<0.001
c-ABR	阈值强度	Y=－0.026X+8.98	0.303	<0.001
Tb-500 Hz ABR	70 dB nHL	Y=0.032X+9.09	0.120	<0.001
Tb-500 Hz ABR	阈值强度	Y=－0.057X+15.59	0.244	<0.001
Tb-1000 Hz ABR	70 dB nHL	Y=0.022X+8.05	0.125	<0.001
Tb-1000 Hz ABR	阈值强度	Y=－0.052X+13.22	0.371	<0.001

Latency-intensity functions of wave Ⅴ in click and tone-burst auditory brainstem responses in infants with varying degrees of sensorineural hearing loss

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