Journal of Clinical Pediatrics ›› 2025, Vol. 43 ›› Issue (8): 569-574.doi: 10.12372/jcp.2025.25e0684

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The significance, progress and challenges of optimizing the protein composition of infant formula based on human breast milk

JIANG Zhuoqin()   

  1. Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, Guangdong, China
  • Received:2025-06-18 Accepted:2025-06-25 Published:2025-08-15 Online:2025-07-28
  • Contact: JIANG Zhuoqin E-mail:jiangzhq@mail.sysu.edu.cn

Abstract:

Human milk is the optimal food for infants. Proteins in human milk provide essential amino acid for growth, and multiple bioactivities for immunity and neurodevelopment. As a breastfeeding substitute, the ultimate goal of infant formula modification is a feeding outcome similar to breast feeding. The strategies to optimize proteins in infant formula including: lower protein content, addition of validated human milk bioactive proteins, adjustment of protein structure based on human milk. Although efforts have been made, there is still a huge gap between human milk and infant formula which need further research.

Key words: human milk, protein, infant formula

CLC Number: 

  • R72