低蛋白血症与新生儿弥散性血管内凝血预后

临床儿科杂志 ›› 2014, Vol. 32 ›› Issue (1): 15-18.

低蛋白血症与新生儿弥散性血管内凝血预后

廖镇宇高喜容

湖南省儿童医院新生儿科 (湖南长沙　410007)

收稿日期:2013-06-02 出版日期:2014-01-15 发布日期:2014-01-15

Relationship between hypoalbuminemia and prognosis of disseminated intravascular coagulation in newborns 　LIAO Zhenyu, GAO Xirong (Department of Neonatology, Hunan Children's Hospital, Changsha 410007, Hunan, China)

Received:2013-06-02 Online:2014-01-15 Published:2014-01-15

摘要/Abstract

摘要：

　目的　探讨低蛋白血症与新生儿弥散性血管内凝血（DIC）预后的相关性。方法　回顾性分析142例DIC新生儿的临床表现、实验室指标和预后等。依据入院24 h内的血清白蛋白水平分为，正常白蛋白组（≥30 g/L）和低白蛋白组（＜30 g/L），分析不同血清白蛋白水平与DIC临床表现、实验室指标及预后的关系。结果　新生儿DIC中，低蛋白血症的发生率为68.3%（97/142）。低白蛋白组病死率（42.3%）高于正常白蛋白组（22.2%），差异有统计学意义（P＜0.05）。与正常白蛋白组比较，低白蛋白组休克和多器官功能障碍的发生率升高，凝血酶原时间（PT）、活性部分凝血活酶时间（APTT）延长，血小板计数降低，差异均有统计学意义（P均＜0.05）。最终死亡新生儿的血清白蛋白水平明显低于存活新生儿，差异有统计学意义（P＜0.05）。结论　低蛋白血症在DIC新生儿中发病率较高，血清白蛋白水平与DIC预后密切相关。

Abstract: 　Objective　To explore the relationship between hypoalbuminemia and prognosis in newborns with disseminated intravascular coagulation (DIC). Methods A total of 142 newborns diagnosed with DIC were divided into normal albumin group (≥30 g/L) and hypoalbuminemia group (<30 g/L) according to the albumin levels within 24 hours of admission. Moreover, the relationship between albumin levels and clinical manifestation, laboratory indices and prognosis of newborns with DIC were analyzed. Results The occurrence rate of hypoalbuminemia in 142 DIC newborns was 68.3% (97/142). The mortality of newborns with DIC in hypoalbuminemia group was 42.3%, significantly higher than that of normal albumin group (22.2%) (P<0.05). Compared with normal albumin group, in hypoalbuminemia group, the rates of shock and multiple organ dysfunction were significantly higher, the prothrombin time (PT) and activated partial thromboplastin time (APTT) were significantly longer, and the platelet count (PLT) was significantly reduced (P<0.05). The level of serum albumin in non-survived group was sinificantly lower than that of the survived group (P<0.05). Conclusions Hypoalbuminemia is common among newborns with DIC, and serum albumin level is closely related to the prognosis.

廖镇宇高喜容. 低蛋白血症与新生儿弥散性血管内凝血预后[J]. 临床儿科杂志, 2014, 32(1): 15-18.

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