晨尿促性腺激素在中枢性性早熟诊断和监测中的应用

doi:10.12372/jcp.2025.25e0393

临床儿科杂志 ›› 2025, Vol. 43 ›› Issue (6): 408-410.doi: 10.12372/jcp.2025.25e0393

晨尿促性腺激素在中枢性性早熟诊断和监测中的应用

戴铖钧, 王春林()

浙江大学医学院附属第一医院儿科（浙江杭州 311100）

收稿日期:2025-04-14 录用日期:2025-05-12 出版日期:2025-06-15 发布日期:2025-06-01
通讯作者: 王春林电子信箱：hzwangcl@zju.edu.cn
基金资助:
国家自然科学基金项目(82270837);浙江省科技厅重点研发计划项目(2020C03121)

The application of morning urinary gonadotropin measurement in the diagnosis and monitoring of central precocious puberty

DAI Chengjun, WANG Chunlin()

Department of Pediatrics, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 311100, Zhejiang, China

Received:2025-04-14 Accepted:2025-05-12 Published:2025-06-15 Online:2025-06-01

摘要/Abstract

摘要：

中枢性性早熟（CPP）对患儿生长潜能及心理健康有显著影响。当前，CPP的诊断主要依赖促性腺激素释放激素激发试验，但该试验过程繁琐且多次采血易造成患者不适。近年来，晨尿促性腺激素检测因其非侵入性和简便性受到关注。本文综述了晨尿促性腺激素检测在CPP诊断中的研究进展，分析其临床应用的可行性，探讨存在的问题及未来发展方向。

关键词: 中枢性性早熟, 晨尿, 促性腺激素, 诊断, 监测

Abstract:

Central precocious puberty (CPP) significantly impacts children's growth potential and psychological well-being. Currently, the diagnosis of CPP primarily relies on the GnRH stimulation test, which is cumbersome and involves multiple blood draws, causing patient discomfort. In recent years, morning urinary gonadotropin measurement has gained attention due to its non-invasiveness and convenience. This article reviews recent advances in urinary gonadotropin testing for CPP diagnosis, analyzes its clinical feasibility, and discusses current challenges and future directions.

Key words: central precocious puberty, morning voided urinary, gonadotropin, diagnosis, monitor

中图分类号:

戴铖钧, 王春林. 晨尿促性腺激素在中枢性性早熟诊断和监测中的应用[J]. 临床儿科杂志, 2025, 43(6): 408-410.

DAI Chengjun, WANG Chunlin. The application of morning urinary gonadotropin measurement in the diagnosis and monitoring of central precocious puberty[J]. Journal of Clinical Pediatrics, 2025, 43(6): 408-410.

参考文献 12

[1]	中华医学会儿科学分会内分泌遗传代谢学组, 中华儿科杂志编辑委员会. 中枢性性早熟诊断与治疗专家共识(2022)[J]. 中华儿科杂志, 2023, 61(1): 16-22.
	The Subspecialty Group of Endocrinologic, Hereditary and Metabolic Diseases, The Society of Pediatrics, Chinese Medical Association; Editorial Board, Chinese Journal of Pediatrics. Expert consensus on the diagnosis and treatment of central precocious puberty (2022)[J]. Zhonghua Erke Zazhi, 2023, 61(1): 16-22.
[2]	Buckler JM, Clayton BE. Output of luteinizing hormone in the urine of normal children and those with advanced sexual development[J]. Arch Dis Child, 1970, 45(242): 478-484. pmid: 5506934
[3]	Witchel SF, Baens-Bailon RG, Lee PA. Treatment of central precocious puberty: comparison of urinary gonadotropin excretion and gonadotropin-releasing hormone (GnRH) stimulation tests in monitoring GnRH analog therapy[J]. J Clin Endocrinol Metab, 1996, 81(4): 1353-1356.
[4]	赵雪奇, 陆文丽, 李文媖, 等. 胶体金法与化学发光法检测晨尿促性腺激素在评估儿童青春发育状态中的应用[J]. 中国当代儿科杂志, 2025, 27(2):199-204.
	Zhao XQ, Lu WL, Li WY, et al. Application of colloidal gold method and chemiluminescence immunoassay for morning urinary gonadotropin measurement in assessing pubertal development in children[J]. Zhongguo Dangdai Erke Zazhi, 2025, 27(2): 199-204.
[5]	Yao Y, Mao S, Yuan K, et al. First morning voided urinary gonadotropins in children: verification of method performance and establishment of reference intervals[J]. Clin Chem Lab Med, 2022, 60(9): 1416-1425. doi: 10.1515/cclm-2022-0296 pmid: 35781120
[6]	Zung A, Burundukov E, Ulman M, et al. The diagnostic value of first-voided urinary LH compared with GNRH-stimulated gonadotropins in differentiating slowly progressive from rapidly progressive precocious puberty in girls[J]. Eur J Endocrinol, 2014, 170(5): 749-758. doi: 10.1530/EJE-14-0010 pmid: 24536086
[7]	Zhan S, Huang K, Wu W, et al. The use of morning urinary gonadotropins and sex hormones in the management of early puberty in Chinese girls[J]. J Clin Endocrinol Metab, 2021, 106(11): e4520-e4530.
[8]	Demir A, Voutilainen R, Stenman UH, et al. First morning voided urinary gonadotropin measurements as an alternative to the GnRH test[J]. Horm Res Paediatr, 2016, 85(5): 301-308.
[9]	Kolby N, Busch AS, Aksglaede L, et al. Nocturnal urinary excretion of FSH and LH in children and adolescents with normal and early puberty[J]. J Clin Endocrinol Metab, 2017, 102(10): 3830-3838. doi: 10.1210/jc.2017-01192 pmid: 28938419
[10]	Xu D, Zhou X, Wang J, et al. The value of urinary gonadotropins in the diagnosis of central precocious puberty: a meta-analysis[J]. BMC Pediatr, 2022, 22(1): 453. doi: 10.1186/s12887-022-03481-1 pmid: 35902824
[11]	Lee SY, Kim JM, Kim YM, et al. Single random measurement of urinary gonadotropin concentration for screening and monitoring girls with central precocious puberty[J]. Ann Pediatr Endocrinol Metab, 2021, 26(3): 178-184.
[12]	Newman M, Pratt SM, Curran DA, et al. Evaluating urinary estrogen and progesterone metabolites using dried filter paper samples and gas chromatography with tandem mass spectrometry (GC-MS/MS)[J]. BMC Chem, 2019, 13(1): 20. doi: 10.1186/s13065-019-0539-1 pmid: 31384769

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晨尿促性腺激素在中枢性性早熟诊断和监测中的应用

The application of morning urinary gonadotropin measurement in the diagnosis and monitoring of central precocious puberty

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