Abstract: Objective To explore the clinical characteristics of neonatal dengue fever. Methods The clinical data from 4 neonates with dengue fever who were admitted and treated in 2014 were retrospectively analyzed and the related literatures had been reviewed. Results Four cases of neonatal dengue fever were all males. Three cases were mother to child transmission, the age at onset was 1 to 7 days after birth, and their mothers suffered with prenatal fever and were diagnozed of dengue fever during perinatal period. One case was community acquired, the age at onset was day 21 after birth and the neonate was bit by mosquito the day before. All four neonates had fever, two cases had rash, and one case had hemorrhagic spot. None of them had jaundice or cough. All of them had thrombocytopenia (30-125)×109/L, prolonged activated partial thromboplastin time (44.0-89.8 s), and increased aspartate aminotransferase (AST) (46-71 U/L). Three cases had declined fibrinogen (1.36-2.53 g/L). Two cases had increased CK-MB (29-86 U/L). Two cases had increased CRP (3.00-46.05 mg/L). After the treatment of anti-infection and intravenous immunoglobulin, all of them were cured and discharged. The duration of hospital stay was 4-17 days. Conclusion The clinical manifestations of neonatal dengue fever were mainly fever and blood coagulation dysfunction, clinical symptoms are mild and lack of specificity, and prognosis are good. Mother to child transmission is one of the ways of dengue virus infection.