Abstract: Objective To explore the correlation between ADAM33 SNP and asthma in Uygur and Han children in Urumqi. Methods Eighty-six Uygur and 111 Han children aged 3-15 years old who had asthma and lived in Urumqi were included. Meanwhile 56 Uygur and 64 Han healthy children were also included as control group. Genotyping of single nucleotide polymorphism (SNP) of V4 and T2 loci in ADAM 33 gene was performed by PCR, and verifications was made. Results There were statistical differences of V4 and T2 loci in ADAM 33 gene among asthma group and control group (P all?  G allelic gene, an allelic gene caused a 1.96-fold increased risk of asthma (95%CI:1.32-2.91). There was no difference of V4 or T2 loci in ADAM 33 gene between asthma group and control group in Han children (P all?>?0.05) while there were differences in Uygur children (P all