血管内皮系统在儿童血管迷走性晕厥发病中的作用研究进展

doi:10.3969/j.issn.1000-3606.2019.01.015

临床儿科杂志 ›› 2019, Vol. 37 ›› Issue (1): 63-66.doi: 10.3969/j.issn.1000-3606.2019.01.015

血管内皮系统在儿童血管迷走性晕厥发病中的作用研究进展

陈婷婷，黄敏，张国琴

上海市儿童医院　上海交通大学附属儿童医院（上海　200062）

出版日期:2019-01-15 发布日期:2019-02-01

Advances in the role of vascular endothelial system in the pathogenesis of vasovagal syncope in children

CHEN Tingting, HUANG Min, ZHANG Guoqing

Children’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200062, China

Online:2019-01-15 Published:2019-02-01

摘要/Abstract

摘要： 血管迷走性晕厥（VVS）是小儿不明原因晕厥中最常见的原因。VVS病因复杂，其诊断主要通过临床表现及直立倾斜试验（HUT）。目前有研究指出，神经内分泌系统在晕厥的发病机制中发挥重要作用，HUT诱发晕厥时伴有异常的神经体液激活。VVS患儿内皮系统分泌的血管内皮素1、一氧化氮等在VVS晕厥发生前后存在血浆浓度改变，提示内皮系统参与儿童VVS的发生。文章综述关于血管内皮系统参与儿童VVS发病机制方面的研究。

关键词: 血管迷走性晕厥；　血管内皮系统；　儿童

Abstract: 　Vasovagal syncope (VVS) is the most common cause of unexplained syncope in children. The etiology of VVS is complex, and its diagnosis is mainly based on clinical manifestations and head-up tilt test (HUT). It has been pointed out that neuroendocrine system plays an important role in the pathogenesis of syncope. HUT-induced syncope is accompanied by abnormal neurohumoral activation. The changes of plasma concentration of endothelin-1 and nitric oxide secreted by endothelial system before and after VVS syncope in children suggest that endothelial system is involved in the occurrence of VVS in children. This article reviews the research on the involvement of vascular endothelial system in the pathogenesis of VVS in children.

Key words: vasovagal syncope;　vascular endothelial system;　child

陈婷婷黄敏张国琴综述黄玉娟审校. 血管内皮系统在儿童血管迷走性晕厥发病中的作用研究进展[J]. 临床儿科杂志, 2019, 37(1): 63-66.

　Reviewer: CHEN Tingting, HUANG Min, ZHANG Guoqing, Reviser: HUANG Yujuan. Advances in the role of vascular endothelial system in the pathogenesis of vasovagal syncope in children[J]. Journal of Clinical Pediatrics, 2019, 37(1): 63-66.

血管内皮系统在儿童血管迷走性晕厥发病中的作用研究进展

Advances in the role of vascular endothelial system in the pathogenesis of vasovagal syncope in children

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