关键词: 　川崎病；　冠脉损害；　正五聚蛋白3；　N末端脑钠肽前体；　儿童

Abstract: Objective　To explore the significance of PTX3 and NT-proBNP as biomarkers in evaluating the coronary artery lesion of Kawasaki disease (KD). Methods　Concentrations of serum PTX3, NT-proBNP and inflammatory cytokines (IL-1β, IL-6, TNF-α) in 64 children with KD on acute and convalescent phases were detected, and color Doppler ultrasound examination was performed on the acute phase. At the same time, 30 children with only respiratory tract infection and 30 healthy children of same age were selected as control groups. Comparison and correlation evaluation were carried out for these data. Receiver operating characteristic curve was used to analyze the diagnostic efficiency of PTX3 and NT-proBNP on the acute phase for KD. Results　Levels of serum PTX3, NT-proBNP and inflammatory cytokines (IL-1β, IL-6, TNF-α) on the acute phase in children with KD were higher than that on convalescent phase, and no statistical difference in two control groups was observed. PTX3 on convalescent phase was still higher than that in control groups, while there was no significant difference for other factors. The difference of serum PTX3 between CAL and NCAL group of children with KD on the acute phase was statistically significant, meanwhile no significant difference for NT-proBNP on the two phases was found. Serum levels of PTX3 and NT-proBNP of all samples were positively correlated with that of IL-1β, IL-6 and TNF-α (γ=0.666, 0.697,0.645 and 0.674, 0.675，0.694, P=0.000). Area under the receiver operating curve of PTX3 and NT-proBNP were 0.909 (95% CI: 0.862-0.957, P=0.000）and 0.918（95% CI: 0.856-0.981, P=0.000）, respectively. Conclusions PTX3 and NT-proBNP reflect qualitative feature and location of coronary vasculitis in KD separately. Joint combination of the both is helpful to KD early diagnosis. PTX3 is related to the status of the the disease activity as well, thus can be used for monitoring the progress of KD.

Key words: Kawasaki disease, coronary artery lesion;　pentraxin-3, NT-pro-brain natriuretie peptide;　child