关键词: IL-17F基因；　基因多态性；　哮喘；　易感性；　儿童

Abstract: 　Objective　To explore the relationship of IL-17F gene polymorphism with asthma susceptibility and IL-17F level. Method　The single nucleotide polymorphisms of rs763780 and rs1889570 in IL-17F gene were determined in 133 asthma children and 114 control children, and the correlation among the polymorphisms and the susceptibility and peripheral blood IL17 level in children with bronchial asthma were analyzed. Results　The frequency of alleles and genotypes in rs1889570 were significantly different between asthma patients and healthy controls (P=0.049, P=0.043). The A allele frequency of rs1889570 in asthma group was significantly higher than that in control group (OR=1.43, 95%CI: 1.001~2.004, P=0.049). The frequency of alleles and genotypes in rs763780 between two groups had no significant difference (P>0.05). There was no difference in IL-17 levels between rs763780 and rs1889570 genotypes in asthma group (P>0.05). Conclusion　The rs1889570 locus of IL-17F gene is associated with the susceptibility to asthma in children and those who carry the A allele are at high risk of asthma.

Key words: IL-17F gene;　polymorphisms;　asthma;　susceptibility;　child