儿童急性T淋巴细胞白血病治疗及预后

doi:10.3969/j.issn.1000-3606.2019.08.019

临床儿科杂志 ›› 2019, Vol. 37 ›› Issue (8): 632-.doi: 10.3969/j.issn.1000-3606.2019.08.019

儿童急性T淋巴细胞白血病治疗及预后

占思政综述,　张乐萍,　曾慧敏审校

北京大学人民医院儿科（北京　100044）

发布日期:2019-08-09

Treatment and prognosis of childhood acute T lymphocytic leukemia

Reviewer: ZHAN Sizheng, Reviser: ZHANG Leping, ZENG Huimin

Department of Pediatrics, Peking University People’s Hospital, Beijing 100044, China

Published:2019-08-09

摘要/Abstract

摘要： 　儿童急性T淋巴细胞白血病（T-ALL）的无事件生存率（EFS）显著低于急性B淋巴细胞白血病（B-ALL），且 T-ALL诱导失败、早期死亡、复发等风险显著高于B-ALL。近年来，各协作组不断调整治疗方案，如使用地塞米松代替泼尼松、应用大剂量甲氨喋呤、监测MRD水平、应用靶向药物等，极大地改善了T-ALL患儿的临床预后。文章综述国内外协作组治疗儿童T-ALL最新临床方案及研究结果。

关键词: 　儿童；　急性T淋巴细胞白血病；　治疗；　预后

Abstract: 　The event-free survival rate (EFS) of childhood acute T-lymphocytic leukemia (T-ALL) was significantly lower than that of acute B-lymphocytic leukemia (B-ALL), and the risk of induction failure, early death, and recurrence of childhood T-ALL was significantly higher than that of B-ALL. In recent years, various collaborative groups have continuously adjusted treatment options including using dexamethasone instead of prednisone, applying high-dose methotrexate, monitoring MRD levels, and applying targeted drugs, which have greatly improved the clinical prognosis of childhood T-ALL. This article summarizes the proposals and results of different collaborative groups' treatments of childhood T-ALL.

Key words: 　childhood;　acute T lymphocytic leukemia;　treatment;　prognosis

占思政. 儿童急性T淋巴细胞白血病治疗及预后[J]. 临床儿科杂志, 2019, 37(8): 632-.

ZHAN Sizheng. Treatment and prognosis of childhood acute T lymphocytic leukemia[J]. Journal of Clinical Pediatrics, 2019, 37(8): 632-.

儿童急性T淋巴细胞白血病治疗及预后

Treatment and prognosis of childhood acute T lymphocytic leukemia

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