人乳活性成分——骨桥蛋白研究进展

doi:10.3969/j.issn.1000-3606.2021.04.019

临床儿科杂志 ›› 2021, Vol. 39 ›› Issue (4): 313-.doi: 10.3969/j.issn.1000-3606.2021.04.019

人乳活性成分——骨桥蛋白研究进展

朱婧 1 综述汪之顼 2 陈同辛 3 审校

1 . 北京市科学技术研究院北京市营养源研究所（北京 100069）；2 . 南京医科大学公共卫生学院儿少卫生与妇幼保健学系（江苏南京 211166）；3 . 上海交通大学医学院附属上海儿童医学中心免疫科（上海 200127）

发布日期:2021-04-15

Research progress in human milk active ingredient-osteopontin

Reviewer: ZHU Jing1 , Reviser: WANG Zhixu2 , CHEN Tongxin3

1 .Beijing Institute of Nutritional Sources, Beijing Academy of Science and Technology, Beijing 100069 , China; 2 . Department of Child and Adolescent Hygiene and Maternal and Child Health, School of Public Health, Nanjing Medical University, Nanjing 211166 , Jiangsu, China; 3 . Department of Immunology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China

Published:2021-04-15

摘要/Abstract

摘要： 骨桥蛋白（OPN）是近年来备受关注的一种高度磷酸化，具有O-糖基化修饰的酸性蛋白。根据OPN在体内的分布，可分为分泌型OPN和细胞内OPN，可由体内多种组织细胞合成或分泌，广泛存在于骨、肾、脑、肌肉等多种组织和细胞中。近年的研究发现，乳汁尤其是初乳中分泌型OPN含量高，且分泌型OPN在生命早期的肠道生长、免疫调节、神经系统发育中发挥着重要作用。本文综述乳汁中OPN对生命早期生长发育和健康作用的研究进展。

关键词: 骨桥蛋白；肠道发育；免疫；婴幼儿

Abstract: Osteopontin (OPN) is a highly phosphorylated acidic protein with O-glycosylation modification and has attracted much attention in recent years. According to the distribution of OPN in the body, it can be divided into secreted OPN and intracellular OPN. It can be synthesized or secreted by a variety of tissues and cells in the body, and widely exists in bone, kidney, brain, muscle and other tissues and cells. Recent studies have found that secretory OPN is high in breast milk, especially in colostrum, and that secretory OPN plays an important role in intestinal growth, immune regulation and nervous system development in early life. This article reviews the research progress in the effects of OPN in milk on early life growth and health.

Key words: osteopontin; intestinal development; immunity; infants and young children

朱婧. 人乳活性成分——骨桥蛋白研究进展[J]. 临床儿科杂志, 2021, 39(4): 313-.

ZHU Jing. Research progress in human milk active ingredient-osteopontin[J]. Journal of Clinical Pediatrics, 2021, 39(4): 313-.

人乳活性成分——骨桥蛋白研究进展

Research progress in human milk active ingredient-osteopontin

PDF (PC)

赞

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 0

Metrics

本文评价

推荐阅读 0