临床儿科杂志 ›› 2014, Vol. 32 ›› Issue (2): 189-192.

• 文献综述 • 上一篇    下一篇

川崎病流行病学、病因和发病机制的新进展

杨波,朱义杰   

  1. 三峡大学仁和医院儿科(湖北宜昌 443001)
  • 收稿日期:2013-08-12 出版日期:2014-02-15 发布日期:2014-02-15

Advances in epidemiology, etiology and pathogenesis of Kawasaki disease

 YANG Bo, ZHU Yijie   

  1. (Department of Pediatrics, Renhe Hospital Affiliated to Sanxia University, Yichang 443001, Hubei, China)
  • Received:2013-08-12 Online:2014-02-15 Published:2014-02-15

摘要:

 川崎病(KD)是一种以急性全身血管炎为主要病理变化的疾病,好发于6个月至4岁的婴幼儿。KD主要累及冠状动脉,导致动脉瘤和血栓形成,引起严重的并发症甚至猝死。目前KD的病因和发病机制尚不完全清楚。文章就KD的流行病学、病因、发病机制及易感因素等新进展作一综述。

关键词: 川崎病; 流行病学; 病因; 发病机制; 基因易感性

Abstract:  Kawasaki disease (KD) is an acute systemic vasculitis that primarily affects young children between 6 months and 4 years old. Coronary arteritis is an important clinical feature of KD because it is associated with aneurysms and thromboembolic events that can lead to severe complications, even sudden death. To date, the etiology and pathogenesis of Kawasaki disease has not been understood completely. In this paper, we will review the recent advances in epidemiology, etiology, pathogenesis and genetic susceptibility of Kawasaki disease.