儿童和青少年成熟B细胞非霍奇金淋巴瘤临床诊治探讨

临床儿科杂志 ›› 2014, Vol. 32 ›› Issue (5): 401-404.

• 专家笔谈 • 下一篇

儿童和青少年成熟B细胞非霍奇金淋巴瘤临床诊治探讨

高怡瑾

上海交通大学医学院附属上海儿童医学中心血液/肿瘤科(上海 200127）

收稿日期:2014-04-01 出版日期:2014-05-15 发布日期:2014-05-15

Treatment of childhood and adolescent mature B-cell lymphoma

GAO Yijin

(Shanghai Children’s Medical Center, Shanghai Jiaotong University, School of Medicine, Shanghai 200127, China)

Received:2014-04-01 Published:2014-05-15 Online:2014-05-15

摘要/Abstract

摘要：

　成熟B细胞非霍奇金淋巴瘤（B-NHL）占儿童和青少年非霍奇金淋巴瘤的55%~60%。以伯基特淋巴瘤和弥漫大B细胞淋巴瘤最为常见。短疗程的多药联合强化疗可使儿童和青少年B-NHL的总体生存率达80%以上。影响B-NHL预后的相关因素包括，骨髓或中枢神经系统受累与否、血清乳酸脱氢酶水平以及化疗后患儿的动态反应。在分子生物学水平上寻找新的危险因子，寻找新的治疗方法以减少治疗相关不良反应是未来临床研究的重点。文章就目前儿童和青少年B-NHL临床诊治要点进行回顾分析。

Abstract: Mature B-cell non-Hodgkin lymphoma (B-NHL) represents about 55%-60% of all NHL cases in children and adolescents. Burkitt lymphoma and diffuse large B-cell lymphoma are the most common subtypes. Current combination chemotherapy regimen succeeds in overall survival rates of more than 80%. Risk factors for the prognosis of childhood and adolescent B-NHL include, bone marrow and central nervous system involvement, serum lactate dehydrogenase level and kinetics of response to therapy. Future strategies should include further understanding of the genetic alternation of B-NHL and utilization of novel target therapies to decrease treatment-related toxicity. We performed a retrospective analysis on the treatment of child and adolescent mature B-cell lymphoma.

高怡瑾. 儿童和青少年成熟B细胞非霍奇金淋巴瘤临床诊治探讨[J]. 临床儿科杂志, 2014, 32(5): 401-404.

GAO Yijin. Treatment of childhood and adolescent mature B-cell lymphoma [J]. , 2014, 32(5): 401-404.

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儿童和青少年成熟B细胞非霍奇金淋巴瘤临床诊治探讨

Treatment of childhood and adolescent mature B-cell lymphoma

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